Replacement therapy for hereditary alpha1-antitrypsin deficiency: A program for long-term administration

Alan Barker, F. Siemsen, D. Pasley, R. D'Silva, A (Sonia) Buist

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

This retrospective chart review describes the efficacy and safety of long- term administration of intravenous alpha1-antitrypsin (AAT) in 14 patients with hereditary AAT deficiency and COPD. During the 12- to 48-month observation period, 12 of 14 patients had stabilization of functional status; 4 patients had reductions in hospitalizations. Thirteen of 14 patients had no decline in pulmonary function. Three patients had self-limited adverse reactions to the AAT with one patient requiring a brief hospitalization.

Original languageEnglish (US)
Pages (from-to)1406-1410
Number of pages5
JournalChest
Volume105
Issue number5
StatePublished - 1994

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Hospitalization
Therapeutics
Intravenous Administration
Chronic Obstructive Pulmonary Disease
Observation
Safety
Lung

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Replacement therapy for hereditary alpha1-antitrypsin deficiency : A program for long-term administration. / Barker, Alan; Siemsen, F.; Pasley, D.; D'Silva, R.; Buist, A (Sonia).

In: Chest, Vol. 105, No. 5, 1994, p. 1406-1410.

Research output: Contribution to journalArticle

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