Replacement oral ethinyloestradiol therapy for gonadal dysgenesis: growth and adrenal androgen studies

A. W. Lucky, S. P. Marynick, R. W. Rebar, G. B. Cutler, M. Glen, R. E. Johnsonbaugh, Donald (Lynn) Loriaux

27 Scopus citations

Abstract

We have studied growth and adrenal dehydroepiandrosterone (DHA) responses to iv synthetic andrenocorticotrophic hormone (ACTH, Cortrosyn) in 6 girls with gonadal dysgenesis before and during treatment with low-dose ethinyloestradiol (EOe 2). In all patients there was a statisfactory induction of secondary sexual characteristics including increase in breasts and pubic hair and onset of withdrawal bleeding within 6 months of therapy. Height velocity increased from 2.8 ± 0.9 cm/year pre-treatment to 5.3 ± 1.5 cm/year (P

Original languageEnglish (US)
Pages (from-to)519-528
Number of pages10
JournalActa Endocrinologica
Volume91
Issue number3
Publication statusPublished - 1979
Externally publishedYes

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ASJC Scopus subject areas

  • Endocrinology

Cite this

Lucky, A. W., Marynick, S. P., Rebar, R. W., Cutler, G. B., Glen, M., Johnsonbaugh, R. E., & Loriaux, D. L. (1979). Replacement oral ethinyloestradiol therapy for gonadal dysgenesis: growth and adrenal androgen studies. Acta Endocrinologica, 91(3), 519-528.