Repeated microinjections into the medial prefrontal cortex (mPFC) impair extinction of conditioned place preference in mice

Peter A. Groblewski, Christopher Cunningham

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The medial prefrontal cortex (mPFC) is important for extinction of many behaviors including conditioned place preference (CPP). We examined the effects of intra-mPFC inactivation (with bupivacaine) on extinction of ethanol-induced CPP in mice. Injections of both bupivacaine and vehicle impaired extinction whereas no-surgery control mice extinguished normally. Consistent with recently reported effects of mPFC lesions, these data suggest that extinction was impaired by excessive mPFC damage induced by repeated intracranial infusions.

Original languageEnglish (US)
Pages (from-to)299-303
Number of pages5
JournalBehavioural Brain Research
Volume230
Issue number1
DOIs
StatePublished - Apr 21 2012

Fingerprint

Microinjections
Prefrontal Cortex
Bupivacaine
Ethanol
Injections
Psychological Extinction

Keywords

  • CPP
  • Ethanol
  • Extinction
  • Intra-cranial
  • Mice
  • MPFC

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Repeated microinjections into the medial prefrontal cortex (mPFC) impair extinction of conditioned place preference in mice. / Groblewski, Peter A.; Cunningham, Christopher.

In: Behavioural Brain Research, Vol. 230, No. 1, 21.04.2012, p. 299-303.

Research output: Contribution to journalArticle

@article{568d7519f88f44fd9880373f181820f9,
title = "Repeated microinjections into the medial prefrontal cortex (mPFC) impair extinction of conditioned place preference in mice",
abstract = "The medial prefrontal cortex (mPFC) is important for extinction of many behaviors including conditioned place preference (CPP). We examined the effects of intra-mPFC inactivation (with bupivacaine) on extinction of ethanol-induced CPP in mice. Injections of both bupivacaine and vehicle impaired extinction whereas no-surgery control mice extinguished normally. Consistent with recently reported effects of mPFC lesions, these data suggest that extinction was impaired by excessive mPFC damage induced by repeated intracranial infusions.",
keywords = "CPP, Ethanol, Extinction, Intra-cranial, Mice, MPFC",
author = "Groblewski, {Peter A.} and Christopher Cunningham",
year = "2012",
month = "4",
day = "21",
doi = "10.1016/j.bbr.2012.01.059",
language = "English (US)",
volume = "230",
pages = "299--303",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Repeated microinjections into the medial prefrontal cortex (mPFC) impair extinction of conditioned place preference in mice

AU - Groblewski, Peter A.

AU - Cunningham, Christopher

PY - 2012/4/21

Y1 - 2012/4/21

N2 - The medial prefrontal cortex (mPFC) is important for extinction of many behaviors including conditioned place preference (CPP). We examined the effects of intra-mPFC inactivation (with bupivacaine) on extinction of ethanol-induced CPP in mice. Injections of both bupivacaine and vehicle impaired extinction whereas no-surgery control mice extinguished normally. Consistent with recently reported effects of mPFC lesions, these data suggest that extinction was impaired by excessive mPFC damage induced by repeated intracranial infusions.

AB - The medial prefrontal cortex (mPFC) is important for extinction of many behaviors including conditioned place preference (CPP). We examined the effects of intra-mPFC inactivation (with bupivacaine) on extinction of ethanol-induced CPP in mice. Injections of both bupivacaine and vehicle impaired extinction whereas no-surgery control mice extinguished normally. Consistent with recently reported effects of mPFC lesions, these data suggest that extinction was impaired by excessive mPFC damage induced by repeated intracranial infusions.

KW - CPP

KW - Ethanol

KW - Extinction

KW - Intra-cranial

KW - Mice

KW - MPFC

UR - http://www.scopus.com/inward/record.url?scp=84858438955&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858438955&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2012.01.059

DO - 10.1016/j.bbr.2012.01.059

M3 - Article

VL - 230

SP - 299

EP - 303

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1

ER -