Repeated microinjections into the medial prefrontal cortex (mPFC) impair extinction of conditioned place preference in mice

Peter A. Groblewski, Christopher Cunningham

2 Scopus citations

Abstract

The medial prefrontal cortex (mPFC) is important for extinction of many behaviors including conditioned place preference (CPP). We examined the effects of intra-mPFC inactivation (with bupivacaine) on extinction of ethanol-induced CPP in mice. Injections of both bupivacaine and vehicle impaired extinction whereas no-surgery control mice extinguished normally. Consistent with recently reported effects of mPFC lesions, these data suggest that extinction was impaired by excessive mPFC damage induced by repeated intracranial infusions.

Original languageEnglish (US)
Pages (from-to)299-303
Number of pages5
JournalBehavioural Brain Research
Volume230
Issue number1
DOIs
Publication statusPublished - Apr 21 2012

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Keywords

  • CPP
  • Ethanol
  • Extinction
  • Intra-cranial
  • Mice
  • MPFC

ASJC Scopus subject areas

  • Behavioral Neuroscience

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