Repeated injections of cocaine inhibit the serotonergic regulation of prolactin and renin secretion in rats

Andrew D. Levy, Peter A. Rittenhouse, Qian Li, Anna M. Bonadonna, Maria C. Alvarez Sanz, Janice E. Kerr, Cynthia Bethea, Louis D. van de Kar

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    Alterations in serotonergic function following repeated cocaine injections were examined using neuroendocrine responses to a serotonin (5-HT) releaser and 5-HT agonists.Forty-two hours following administration of cocaine (1-15 mg/kg i.p.) twice daily for 7 or 30 days, male Sprague-Dawley rats were injected with the 5-HT releaser p-chloroamphetamine (PCA; 8 mg/kg i.p.) and blood samples were collected 1 h later for radioimmunoassays of plasma prolactin, plasma renin activity (PRA) and plasma renin concentration (PRC). PCA significantly increased secretion of prolactin and renin. These responses were attenuated in rats pretreated with cocaine for 30 days. In rats receiving cocaine for 7 days, the attenuation of PCA-induced secretion of prolactin and renin was less consistently observed. To determine whether these alterations were due to pre- or postsynaptic effects, rats were injected with cocaine (15 mg/kg i.p.) twice daily for 7 days, and the neuroendocrine responses to the direct 5-HT agonists RU 24969 and m-CPP were examined, 42 h after the last cocaine injection. Pretreatment with cocaine potentiated RU 24969-induced stimulation of plasma prolactin concentration. However, cocaine did not alter the ability of m-CPP to increase plasma prolactin concentrations. The stimulation of renin secretion in response to both 5-HT agonists was not altered by cocaine pretreatment. The data suggest that repeated cocaine impairs the function of serotonergic nerve terminals that regulate these endocrine responses. Furthermore, the 5-HT receptors that mediate prolactin secretion may exhibit supersensitivity.

    Original languageEnglish (US)
    Pages (from-to)6-11
    Number of pages6
    JournalBrain Research
    Volume580
    Issue number1-2
    DOIs
    StatePublished - May 15 1992

    Fingerprint

    Cocaine
    Renin
    Prolactin
    Injections
    Serotonin Receptor Agonists
    Passive Cutaneous Anaphylaxis
    Serotonin
    p-Chloroamphetamine
    Serotonin Receptors
    Radioimmunoassay
    Sprague Dawley Rats

    Keywords

    • Chronic
    • Cocaine
    • Neuroendocrine
    • Prolactin
    • Renin
    • Serotonin

    ASJC Scopus subject areas

    • Developmental Biology
    • Molecular Biology
    • Clinical Neurology
    • Neuroscience(all)

    Cite this

    Levy, A. D., Rittenhouse, P. A., Li, Q., Bonadonna, A. M., Alvarez Sanz, M. C., Kerr, J. E., ... van de Kar, L. D. (1992). Repeated injections of cocaine inhibit the serotonergic regulation of prolactin and renin secretion in rats. Brain Research, 580(1-2), 6-11. https://doi.org/10.1016/0006-8993(92)90920-5

    Repeated injections of cocaine inhibit the serotonergic regulation of prolactin and renin secretion in rats. / Levy, Andrew D.; Rittenhouse, Peter A.; Li, Qian; Bonadonna, Anna M.; Alvarez Sanz, Maria C.; Kerr, Janice E.; Bethea, Cynthia; van de Kar, Louis D.

    In: Brain Research, Vol. 580, No. 1-2, 15.05.1992, p. 6-11.

    Research output: Contribution to journalArticle

    Levy, AD, Rittenhouse, PA, Li, Q, Bonadonna, AM, Alvarez Sanz, MC, Kerr, JE, Bethea, C & van de Kar, LD 1992, 'Repeated injections of cocaine inhibit the serotonergic regulation of prolactin and renin secretion in rats', Brain Research, vol. 580, no. 1-2, pp. 6-11. https://doi.org/10.1016/0006-8993(92)90920-5
    Levy, Andrew D. ; Rittenhouse, Peter A. ; Li, Qian ; Bonadonna, Anna M. ; Alvarez Sanz, Maria C. ; Kerr, Janice E. ; Bethea, Cynthia ; van de Kar, Louis D. / Repeated injections of cocaine inhibit the serotonergic regulation of prolactin and renin secretion in rats. In: Brain Research. 1992 ; Vol. 580, No. 1-2. pp. 6-11.
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    abstract = "Alterations in serotonergic function following repeated cocaine injections were examined using neuroendocrine responses to a serotonin (5-HT) releaser and 5-HT agonists.Forty-two hours following administration of cocaine (1-15 mg/kg i.p.) twice daily for 7 or 30 days, male Sprague-Dawley rats were injected with the 5-HT releaser p-chloroamphetamine (PCA; 8 mg/kg i.p.) and blood samples were collected 1 h later for radioimmunoassays of plasma prolactin, plasma renin activity (PRA) and plasma renin concentration (PRC). PCA significantly increased secretion of prolactin and renin. These responses were attenuated in rats pretreated with cocaine for 30 days. In rats receiving cocaine for 7 days, the attenuation of PCA-induced secretion of prolactin and renin was less consistently observed. To determine whether these alterations were due to pre- or postsynaptic effects, rats were injected with cocaine (15 mg/kg i.p.) twice daily for 7 days, and the neuroendocrine responses to the direct 5-HT agonists RU 24969 and m-CPP were examined, 42 h after the last cocaine injection. Pretreatment with cocaine potentiated RU 24969-induced stimulation of plasma prolactin concentration. However, cocaine did not alter the ability of m-CPP to increase plasma prolactin concentrations. The stimulation of renin secretion in response to both 5-HT agonists was not altered by cocaine pretreatment. The data suggest that repeated cocaine impairs the function of serotonergic nerve terminals that regulate these endocrine responses. Furthermore, the 5-HT receptors that mediate prolactin secretion may exhibit supersensitivity.",
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