Repeated exposure to cocaine produces long-lasting deficits in the serotonergic stimulation of prolactin and renin, but not adrenocorticotropin secretion

Andrew D. Levy, Peter A. Rittenhouse, Anna M. Bonadonna, Maria C. Alvarez Sanz, Cynthia L. Bethea, Louis D. Van de Kar

    Research output: Contribution to journalArticle

    17 Scopus citations

    Abstract

    To determine whether cocaine-induced deficits in serotonergic function are long-lasting, the neuroendocrine responses to the serotonin (5-hydroxytryptamine, 5-HT) releaser, p-chloroamphetamine were evaluated 1-8 weeks subsequent to 7 days of cocaine exposure (15 mg/kg b.i.d.). In cocaine-pretreated rats, the p-chloroamphetamine-induced elevations of prolactin and renin secretion were significantly reduced for 8 and 4 weeks, respectively. In contrast, the p-chloroamphetamine-induced elevation of adrenocorticotropic hormone (ACTH) secretion was at control values 1 week after cocaine exposure. The data suggest that some cocaine-induced deficits in serotonergic function are long-lasting.

    Original languageEnglish (US)
    Pages (from-to)275-278
    Number of pages4
    JournalEuropean Journal of Pharmacology
    Volume241
    Issue number2-3
    DOIs
    StatePublished - Sep 14 1993

    Keywords

    • 5-HT (5-hydroxytryptamine, serotonin)
    • ACTH (adrenocorticotropic hormone)
    • Cocaine (neuroendocrine)
    • Prolactin
    • Renin

    ASJC Scopus subject areas

    • Pharmacology

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