Repeatability of laser in situ keratomileusis flap thickness measurement by Fourier-domain optical coherence tomography

Camila Haydée Rosas Salaroli, Yan Li, Xinbo Zhang, Maolong Tang, José Luiz Branco Ramos, Norma Allemann, David Huang

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Purpose: To evaluate the repeatability of Fourier-domain optical coherence tomography (OCT) measurements of the thickness of femtosecond laser-created laser in situ keratomileusis (LASIK) flaps. Setting: Doheny Eye Institute, University of Southern California, Los Angeles, California, USA. Design: Case series, evaluation of diagnostic technology. Methods: In this consecutive series, Fourier-domain OCT (RTVue) was used to measure flap thickness 1 week after LASIK. Flaps were created with a Pulsion 60 kHz femtosecond laser programmed for 110 μm flap thickness. Each eye was scanned 2 times with a radial pachymetry pattern and 1 time with a horizontal line scan. Flap thicknesses were measured at 6 positions across the corneal flap (ie, ±0.5 mm, ±1.5 mm, and ±2.5 mm from the center on the horizontal and vertical meridians). The within-grader flap thickness repeatability and between-grader reproducibility were calculated by pooled standard deviations (SDs). Results: Twenty-one eyes were measured. The mean flap thickness measurements were highly predictable at all positions. Thickness SDs varied from 5.3 to 9.5 μm and uniformity, from 121.7 to 126.5 μm. The within-grader repeatability was 3.3 to 6.4 μm based on the same image measured at different times and 4.7 to 7.4 μm for different images. The between-grader reproducibility was 4.0 to 9.0 μm. There was no statistically significant asymmetry between the nasal side and the temporal side, the superior side and the inferior side, or the pericentral area and the central area of the corneal flap. Conclusions: The femtosecond laser created LASIK flaps with uniform and predictable thicknesses. Fourier-domain OCT gave highly repeatable flap-thickness measurements. Financial Disclosure: Drs. Rosas Salaroli, Zhang, Branco Ramos, and Allemann have no financial or proprietary interest in any material or method mentioned. Additional disclosures are found in the footnotes.

Original languageEnglish (US)
Pages (from-to)649-654
Number of pages6
JournalJournal of Cataract and Refractive Surgery
Volume37
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

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Laser In Situ Keratomileusis
Optical Coherence Tomography
Lasers
Disclosure
Meridians
Los Angeles
Fourier Analysis
Nose
Technology

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Surgery

Cite this

Repeatability of laser in situ keratomileusis flap thickness measurement by Fourier-domain optical coherence tomography. / Rosas Salaroli, Camila Haydée; Li, Yan; Zhang, Xinbo; Tang, Maolong; Branco Ramos, José Luiz; Allemann, Norma; Huang, David.

In: Journal of Cataract and Refractive Surgery, Vol. 37, No. 4, 04.2011, p. 649-654.

Research output: Contribution to journalArticle

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abstract = "Purpose: To evaluate the repeatability of Fourier-domain optical coherence tomography (OCT) measurements of the thickness of femtosecond laser-created laser in situ keratomileusis (LASIK) flaps. Setting: Doheny Eye Institute, University of Southern California, Los Angeles, California, USA. Design: Case series, evaluation of diagnostic technology. Methods: In this consecutive series, Fourier-domain OCT (RTVue) was used to measure flap thickness 1 week after LASIK. Flaps were created with a Pulsion 60 kHz femtosecond laser programmed for 110 μm flap thickness. Each eye was scanned 2 times with a radial pachymetry pattern and 1 time with a horizontal line scan. Flap thicknesses were measured at 6 positions across the corneal flap (ie, ±0.5 mm, ±1.5 mm, and ±2.5 mm from the center on the horizontal and vertical meridians). The within-grader flap thickness repeatability and between-grader reproducibility were calculated by pooled standard deviations (SDs). Results: Twenty-one eyes were measured. The mean flap thickness measurements were highly predictable at all positions. Thickness SDs varied from 5.3 to 9.5 μm and uniformity, from 121.7 to 126.5 μm. The within-grader repeatability was 3.3 to 6.4 μm based on the same image measured at different times and 4.7 to 7.4 μm for different images. The between-grader reproducibility was 4.0 to 9.0 μm. There was no statistically significant asymmetry between the nasal side and the temporal side, the superior side and the inferior side, or the pericentral area and the central area of the corneal flap. Conclusions: The femtosecond laser created LASIK flaps with uniform and predictable thicknesses. Fourier-domain OCT gave highly repeatable flap-thickness measurements. Financial Disclosure: Drs. Rosas Salaroli, Zhang, Branco Ramos, and Allemann have no financial or proprietary interest in any material or method mentioned. Additional disclosures are found in the footnotes.",
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AU - Branco Ramos, José Luiz

AU - Allemann, Norma

AU - Huang, David

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