Repeatability of cerebral perfusion using dynamic susceptibility contrast MRI in glioblastoma patients

Kourosh Jafari-Khouzani, Kyrre E. Emblem, Jayashree Kalpathy-Cramer, Atle Bjørnerud, Mark G. Vangel, Elizabeth R. Gerstner, Kathleen M. Schmainda, Kamran Paynabar, Ona Wu, Patrick Y. Wen, Tracy Batchelor, Bruce Rosen, Steven M. Stufflebeam

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

OBJECTIVES: This study evaluates the repeatability of brain perfusion using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with a variety of post-processing methods. METHODS: Thirty-two patients with newly diagnosed glioblastoma were recruited. On a 3-T MRI using a dual-echo, gradient-echo spin-echo DSC-MRI protocol, the patients were scanned twice 1 to 5 days apart. Perfusion maps including cerebral blood volume (CBV) and cerebral blood flow (CBF) were generated using two contrast agent leakage correction methods, along with testing normalization to reference tissue, and application of arterial input function (AIF). Repeatability of CBV and CBF within tumor regions and healthy tissues, identified by structural images, was assessed with intra-class correlation coefficients (ICCs) and repeatability coefficients (RCs). Coefficients of variation (CVs) were reported for selected methods. RESULTS: CBV and CBF were highly repeatable within tumor with ICC values up to 0.97. However, both CBV and CBF showed lower ICCs for healthy cortical tissues (up to 0.83), healthy gray matter (up to 0.95), and healthy white matter (WM; up to 0.93). The values of CV ranged from 6% to 10% in tumor and 3% to 11% in healthy tissues. The values of RC relative to the mean value of measurement within healthy WM ranged from 22% to 42% in tumor and 7% to 43% in healthy tissues. These percentages show how much variation in perfusion parameter, relative to that in healthy WM, we expect to observe to

Original languageEnglish (US)
Pages (from-to)137-146
Number of pages10
JournalTranslational Oncology
Volume8
Issue number3
DOIs
StatePublished - 2015
Externally publishedYes

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Cerebrovascular Circulation
Glioblastoma
Perfusion
Neoplasms
Magnetic Resonance Imaging
Contrast Media
Cerebral Blood Volume
Brain

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Jafari-Khouzani, K., Emblem, K. E., Kalpathy-Cramer, J., Bjørnerud, A., Vangel, M. G., Gerstner, E. R., ... Stufflebeam, S. M. (2015). Repeatability of cerebral perfusion using dynamic susceptibility contrast MRI in glioblastoma patients. Translational Oncology, 8(3), 137-146. https://doi.org/10.1016/j.tranon.2015.03.002

Repeatability of cerebral perfusion using dynamic susceptibility contrast MRI in glioblastoma patients. / Jafari-Khouzani, Kourosh; Emblem, Kyrre E.; Kalpathy-Cramer, Jayashree; Bjørnerud, Atle; Vangel, Mark G.; Gerstner, Elizabeth R.; Schmainda, Kathleen M.; Paynabar, Kamran; Wu, Ona; Wen, Patrick Y.; Batchelor, Tracy; Rosen, Bruce; Stufflebeam, Steven M.

In: Translational Oncology, Vol. 8, No. 3, 2015, p. 137-146.

Research output: Contribution to journalArticle

Jafari-Khouzani, K, Emblem, KE, Kalpathy-Cramer, J, Bjørnerud, A, Vangel, MG, Gerstner, ER, Schmainda, KM, Paynabar, K, Wu, O, Wen, PY, Batchelor, T, Rosen, B & Stufflebeam, SM 2015, 'Repeatability of cerebral perfusion using dynamic susceptibility contrast MRI in glioblastoma patients', Translational Oncology, vol. 8, no. 3, pp. 137-146. https://doi.org/10.1016/j.tranon.2015.03.002
Jafari-Khouzani K, Emblem KE, Kalpathy-Cramer J, Bjørnerud A, Vangel MG, Gerstner ER et al. Repeatability of cerebral perfusion using dynamic susceptibility contrast MRI in glioblastoma patients. Translational Oncology. 2015;8(3):137-146. https://doi.org/10.1016/j.tranon.2015.03.002
Jafari-Khouzani, Kourosh ; Emblem, Kyrre E. ; Kalpathy-Cramer, Jayashree ; Bjørnerud, Atle ; Vangel, Mark G. ; Gerstner, Elizabeth R. ; Schmainda, Kathleen M. ; Paynabar, Kamran ; Wu, Ona ; Wen, Patrick Y. ; Batchelor, Tracy ; Rosen, Bruce ; Stufflebeam, Steven M. / Repeatability of cerebral perfusion using dynamic susceptibility contrast MRI in glioblastoma patients. In: Translational Oncology. 2015 ; Vol. 8, No. 3. pp. 137-146.
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abstract = "OBJECTIVES: This study evaluates the repeatability of brain perfusion using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with a variety of post-processing methods. METHODS: Thirty-two patients with newly diagnosed glioblastoma were recruited. On a 3-T MRI using a dual-echo, gradient-echo spin-echo DSC-MRI protocol, the patients were scanned twice 1 to 5 days apart. Perfusion maps including cerebral blood volume (CBV) and cerebral blood flow (CBF) were generated using two contrast agent leakage correction methods, along with testing normalization to reference tissue, and application of arterial input function (AIF). Repeatability of CBV and CBF within tumor regions and healthy tissues, identified by structural images, was assessed with intra-class correlation coefficients (ICCs) and repeatability coefficients (RCs). Coefficients of variation (CVs) were reported for selected methods. RESULTS: CBV and CBF were highly repeatable within tumor with ICC values up to 0.97. However, both CBV and CBF showed lower ICCs for healthy cortical tissues (up to 0.83), healthy gray matter (up to 0.95), and healthy white matter (WM; up to 0.93). The values of CV ranged from 6{\%} to 10{\%} in tumor and 3{\%} to 11{\%} in healthy tissues. The values of RC relative to the mean value of measurement within healthy WM ranged from 22{\%} to 42{\%} in tumor and 7{\%} to 43{\%} in healthy tissues. These percentages show how much variation in perfusion parameter, relative to that in healthy WM, we expect to observe to",
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AU - Emblem, Kyrre E.

AU - Kalpathy-Cramer, Jayashree

AU - Bjørnerud, Atle

AU - Vangel, Mark G.

AU - Gerstner, Elizabeth R.

AU - Schmainda, Kathleen M.

AU - Paynabar, Kamran

AU - Wu, Ona

AU - Wen, Patrick Y.

AU - Batchelor, Tracy

AU - Rosen, Bruce

AU - Stufflebeam, Steven M.

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N2 - OBJECTIVES: This study evaluates the repeatability of brain perfusion using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with a variety of post-processing methods. METHODS: Thirty-two patients with newly diagnosed glioblastoma were recruited. On a 3-T MRI using a dual-echo, gradient-echo spin-echo DSC-MRI protocol, the patients were scanned twice 1 to 5 days apart. Perfusion maps including cerebral blood volume (CBV) and cerebral blood flow (CBF) were generated using two contrast agent leakage correction methods, along with testing normalization to reference tissue, and application of arterial input function (AIF). Repeatability of CBV and CBF within tumor regions and healthy tissues, identified by structural images, was assessed with intra-class correlation coefficients (ICCs) and repeatability coefficients (RCs). Coefficients of variation (CVs) were reported for selected methods. RESULTS: CBV and CBF were highly repeatable within tumor with ICC values up to 0.97. However, both CBV and CBF showed lower ICCs for healthy cortical tissues (up to 0.83), healthy gray matter (up to 0.95), and healthy white matter (WM; up to 0.93). The values of CV ranged from 6% to 10% in tumor and 3% to 11% in healthy tissues. The values of RC relative to the mean value of measurement within healthy WM ranged from 22% to 42% in tumor and 7% to 43% in healthy tissues. These percentages show how much variation in perfusion parameter, relative to that in healthy WM, we expect to observe to

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