Renal transport of organic acids and bases in aminoglycoside nephrotoxicity

W. M. Bennett, C. E. Plamp, R. A. Parker, D. N. Gilbert, D. C. Houghton, G. A. Porter

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The effects of aminoglycoside antibiotics on the transport of p-aminohippurate and N-methylnicotinamide was measured in renal cortical slices of male Fischer rats. The p-aminohippurate transport pattern of early stimulation followed by late suppression appears to be characteristic of aminoglycosides which produce overt nephrotoxicity. In this rat model, neomycin is more nephrotoxic than gentamicin, which is more nephrotoxic than tobramycin.

Original languageEnglish (US)
Pages (from-to)231-233
Number of pages3
JournalUnknown Journal
Issue number2
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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