Renal transport of organic acids and bases in aminoglycoside nephrotoxicity

W. M. Bennett, C. E. Plamp, Richard Parker, D. N. Gilbert, Donald Houghton, G. A. Porter

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effects of aminoglycoside antibiotics on the transport of p-aminohippurate and N-methylnicotinamide was measured in renal cortical slices of male Fischer rats. The p-aminohippurate transport pattern of early stimulation followed by late suppression appears to be characteristic of aminoglycosides which produce overt nephrotoxicity. In this rat model, neomycin is more nephrotoxic than gentamicin, which is more nephrotoxic than tobramycin.

Original languageEnglish (US)
Pages (from-to)231-233
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume16
Issue number2
StatePublished - 1979

Fingerprint

p-Aminohippuric Acid
Aminoglycosides
Kidney
Tobramycin
Acids
Neomycin
Inbred F344 Rats
Gentamicins
Anti-Bacterial Agents
N-methylnicotinamide

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Bennett, W. M., Plamp, C. E., Parker, R., Gilbert, D. N., Houghton, D., & Porter, G. A. (1979). Renal transport of organic acids and bases in aminoglycoside nephrotoxicity. Antimicrobial Agents and Chemotherapy, 16(2), 231-233.

Renal transport of organic acids and bases in aminoglycoside nephrotoxicity. / Bennett, W. M.; Plamp, C. E.; Parker, Richard; Gilbert, D. N.; Houghton, Donald; Porter, G. A.

In: Antimicrobial Agents and Chemotherapy, Vol. 16, No. 2, 1979, p. 231-233.

Research output: Contribution to journalArticle

Bennett, WM, Plamp, CE, Parker, R, Gilbert, DN, Houghton, D & Porter, GA 1979, 'Renal transport of organic acids and bases in aminoglycoside nephrotoxicity', Antimicrobial Agents and Chemotherapy, vol. 16, no. 2, pp. 231-233.
Bennett, W. M. ; Plamp, C. E. ; Parker, Richard ; Gilbert, D. N. ; Houghton, Donald ; Porter, G. A. / Renal transport of organic acids and bases in aminoglycoside nephrotoxicity. In: Antimicrobial Agents and Chemotherapy. 1979 ; Vol. 16, No. 2. pp. 231-233.
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