Renal transport of organic acids and bases in aminoglycoside nephrotoxicity

W. M. Bennett, C. E. Plamp, R. A. Parker, D. N. Gilbert, D. C. Houghton, G. A. Porter

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The effects of aminoglycoside antibiotics on the transport of p-aminohippurate and N-methylnicotinamide was measured in renal cortical slices of male Fischer rats. The p-aminohippurate transport pattern of early stimulation followed by late suppression appears to be characteristic of aminoglycosides which produce overt nephrotoxicity. In this rat model, neomycin is more nephrotoxic than gentamicin, which is more nephrotoxic than tobramycin.

Original languageEnglish (US)
Pages (from-to)231-233
Number of pages3
JournalUnknown Journal
Volume16
Issue number2
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Bennett, W. M., Plamp, C. E., Parker, R. A., Gilbert, D. N., Houghton, D. C., & Porter, G. A. (1979). Renal transport of organic acids and bases in aminoglycoside nephrotoxicity. Unknown Journal, 16(2), 231-233. https://doi.org/10.1128/AAC.16.2.231