Renal Stem Cell Biology Starts to Take Spherical Shape Commentary on: Lusis et al., Isolation of clonogenic, long-term self renewing embryonic renal stem cells

Jinu Abraham, Charles Keller

Research output: Contribution to journalEditorial

1 Scopus citations

Abstract

The nephron is the fundamental unit of renal function, yet the ability of the kidney to regenerate nephrons after birth is limited. Due to the medical and financial impact of chronic and end stage renal disease, an improved understanding of nephron formation is necessary if regenerative or cell therapy are to be a feasible alternative to dialysis or renal transplant. In the study presented by Lusis et al., the presence of metanephric mesenchymal stem cells is definitively demonstrated. However, these "Nephrospheres" have characteristics of mesenchymal stem cells and substantially lack the ability to undergo an epithelial-to-mesenchyme transition or to form epithelial elements otherwise necessary for building the constituent cells of the nephron. Nevertheless, this newly isolated cell population opens many opportunities to investigate the consequences of normal and aberrant nephrogenesis, including Wilm's tumor.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalStem Cell Research
Volume5
Issue number1
DOIs
StatePublished - Jul 1 2010

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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