Renal neoplasms mimicking rhabdoid tumor of kidney

A report from the National Wilms' Tumor Study Pathology Center

Douglas Weeks, J. B. Beckwith, G. W. Mierau, C. W. Zuppan

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Fifty-six renal neoplasms reviewed by the National Wilms' Tumor Study Pathology Center presented with histologic features that resulted in confusion with rhabdoid tumor of kidney, a usually lethal childhood renal tumor; all were eventually diagnosed as other entities. Conspicuous filamentous cytoplasmic inclusions or large nucleoli, typical findings in rhabdoid renal tumors, were the usual source of diagnostic difficulty. Most, but not all, tumors occurred in pediatric patients. Sixteen were examples of Favorable Histology Wilms' tumor, which invited confusion with rhabdoid tumors either on the basis of filamentous cytoplasmic inclusions (15 cases) or macronucleoli (one case). In most cases, foci of typical Wilms' tumor blastemal aggregation or evidence of definitive nephrogenic differentiation facilitated the correct diagnosis. All 10 patients for whom information about outcome was available were alive at last follow-up. The other 40 renal lesions mimicking rhabdoid tumor of kidney consisted of a clinically and histogenetically diverse group of neoplasms, including anaplastic Wilms' tumor, congenital mesoblastic nephroma, renal cell carcinoma, transitional cell carcinoma, collecting-duct carcinoma, oncocytoma, rhabdomyosarcoma, malignant neuroepithelial tumors, and lymphoma. Most of these lesions could be separated from renal rhabdoid tumors and correctly classified on the basis of careful attention to light microscopic details, but in several cases electron microscopy or immunocytochemical studies were helpful or essential.

Original languageEnglish (US)
Pages (from-to)1042-1054
Number of pages13
JournalAmerican Journal of Surgical Pathology
Volume15
Issue number11
StatePublished - 1991
Externally publishedYes

Fingerprint

Rhabdoid Tumor
Wilms Tumor
Kidney Neoplasms
Pathology
Kidney
Inclusion Bodies
Renal Cell Carcinoma
Mesoblastic Nephroma
Neuroepithelial Neoplasms
Oxyphilic Adenoma
Neoplasms
Rhabdomyosarcoma
Transitional Cell Carcinoma
Lymphoma
Histology
Electron Microscopy
Pediatrics
Light

Keywords

  • Filamentous cytoplasmic inclusions
  • Rhabdoid tumor
  • Wilms' tumor

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Renal neoplasms mimicking rhabdoid tumor of kidney : A report from the National Wilms' Tumor Study Pathology Center. / Weeks, Douglas; Beckwith, J. B.; Mierau, G. W.; Zuppan, C. W.

In: American Journal of Surgical Pathology, Vol. 15, No. 11, 1991, p. 1042-1054.

Research output: Contribution to journalArticle

Weeks, Douglas ; Beckwith, J. B. ; Mierau, G. W. ; Zuppan, C. W. / Renal neoplasms mimicking rhabdoid tumor of kidney : A report from the National Wilms' Tumor Study Pathology Center. In: American Journal of Surgical Pathology. 1991 ; Vol. 15, No. 11. pp. 1042-1054.
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