Renal neomycin exretion in the dog

W. J. Stone, Richard Bryant, A. Hoyumpa, S. Schenker

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Abstract

The mechanism(s) of renal neomycin excretion in dogs was examined. Neomycin is approximately 40% bound to serum protein and the mean neomycin fractional excretion is 68%. Since the sum of protein binding and the fractional excretion of neomycin approximates 100%, the low molecular weight of neomycin should facilitate its filtration, and other aminoglycosides like gentamicin which are not bound to protein have not been shown to be absorbed or secreted by renal tubules, it appears likely that glomerular filtration is the main mechanism responsible for neomycin excretion by the kidney.

Original languageEnglish (US)
Pages (from-to)1074-1080
Number of pages7
JournalProceedings of the Society for Experimental Biology and Medicine
Volume145
Issue number3
Publication statusPublished - 1974
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Stone, W. J., Bryant, R., Hoyumpa, A., & Schenker, S. (1974). Renal neomycin exretion in the dog. Proceedings of the Society for Experimental Biology and Medicine, 145(3), 1074-1080.