Renal mineralocorticoid receptor and electrolyte homeostasis

Andrew S. Terker, David H. Ellison

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

The renal mineralocorticoid receptor (MR) is a steroid hormone receptor essential for maintaining electrolyte homeostasis. Its role in mediating effects of aldosterone was likely vital in enabling the evolution of terrestrial life. Dysregulated aldosterone-MR signaling has been identified as the cause of multiple clinical diseases, suggesting the physiological importance of the MR. While the physiology of this pathway has been studied for over 60 years, only more recently have genetic mouse models been available to dissect its function in vivo. This review will focus on recent advances in our knowledge of MR function with an emphasis on these models.

Original languageEnglish (US)
Pages (from-to)R1068-R1070
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume309
Issue number9
DOIs
StatePublished - 2015

Keywords

  • Homeostasis
  • Mineralocorticoid
  • Na Cl cotransporter
  • Potassium
  • Sodium

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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