Renal ischemia

Does sex matter?

Michael Hutchens, Jennifer Dunlap, Patricia D. Hurn, Per-Olof Järnberg

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Renal ischemia is a common complication in the perioperative period that leads to a high rate of morbidity and mortality. As in other forms of ischemia (i.e., cardiac, neurologic), the incidence and outcome of renal ischemia is strikingly sex-specific. Sexual dimorphism in response to renal injury has been noted for many years, but is now the subject of both clinical and experimental research. Clinically, women experience a lower incidence of perioperative acute renal failure, with the exception of cardiac surgery. Experimental science is now producing tantalizing clues that sex steroids, both male and female, play a role in the kidney's response to ischemia. In this review, we evaluated sex differences in perioperative renal failure and in the pathophysiology of renal ischemia/reperfusion injury. Although much work remains to characterize the biological mechanisms involved, the data are sufficient to support consideration of gender and the use of medications that impact steroid availability in the perioperative plan of care.

Original languageEnglish (US)
Pages (from-to)239-249
Number of pages11
JournalAnesthesia and Analgesia
Volume107
Issue number1
DOIs
StatePublished - Jul 2008

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Ischemia
Kidney
Sex Characteristics
Steroids
Perioperative Care
Perioperative Period
Incidence
Reperfusion Injury
Acute Kidney Injury
Nervous System
Thoracic Surgery
Renal Insufficiency
Morbidity
Mortality
Wounds and Injuries
Research

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Renal ischemia : Does sex matter? / Hutchens, Michael; Dunlap, Jennifer; Hurn, Patricia D.; Järnberg, Per-Olof.

In: Anesthesia and Analgesia, Vol. 107, No. 1, 07.2008, p. 239-249.

Research output: Contribution to journalArticle

Hutchens, Michael ; Dunlap, Jennifer ; Hurn, Patricia D. ; Järnberg, Per-Olof. / Renal ischemia : Does sex matter?. In: Anesthesia and Analgesia. 2008 ; Vol. 107, No. 1. pp. 239-249.
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