Renal IGF-1 mRNA levels are enhanced following unilateral nephrectomy in immature but not adult rats

Susan E. Mulroney, Aviad Haramati, Charles Roberts, Derek Leroith

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The increase in IGF-1 gene expression following unilateral nephrectomy (UNX) in adult rats is controversial. In this study we have examined whether developmental differences exist in the effect of UNX on IGF-1 gene expression. Immature (23 days) and adult (4 months) Wistar rats underwent a sham operation or left UNX, and were sacrificed 24 or 48 hrs later. IGF-1 mRNA levels were determined in left (control) and right (compensated) kidneys using solution hybridization/RNase protection assays. By 48 hrs post-UNX, remnant kidneys had grown 20±1% in adult rats (P

Original languageEnglish (US)
Pages (from-to)2660-2662
Number of pages3
JournalEndocrinology
Volume128
Issue number5
StatePublished - May 1991
Externally publishedYes

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Nephrectomy
Insulin-Like Growth Factor I
Kidney
Messenger RNA
Gene Expression
Ribonucleases
Wistar Rats

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Renal IGF-1 mRNA levels are enhanced following unilateral nephrectomy in immature but not adult rats. / Mulroney, Susan E.; Haramati, Aviad; Roberts, Charles; Leroith, Derek.

In: Endocrinology, Vol. 128, No. 5, 05.1991, p. 2660-2662.

Research output: Contribution to journalArticle

Mulroney, Susan E. ; Haramati, Aviad ; Roberts, Charles ; Leroith, Derek. / Renal IGF-1 mRNA levels are enhanced following unilateral nephrectomy in immature but not adult rats. In: Endocrinology. 1991 ; Vol. 128, No. 5. pp. 2660-2662.
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