Renal fluoride excretion and plasma fluoride levels during and after enflurane anesthesia are dependent on urinary pH

Per-Olof Järnberg, J. Ekstrand, L. Irestedt

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

To determine the effects of urinary pH on fluoride ion excretion and the resulting plasma fluoride concentrations during and after enflurane anesthesia, renal function, plasma inorganic fluoride levels, and fluoride excretion were studied in two groups of patients pretreated with either NH4Cl or acetazolamide to produce acidic or alkaline urine, respectively. During anesthesia, urinary flow rate, inulin clearance (C(In)) and para-aminohippurate (PAH) clearance (C(PAH)) were 7, 61, and 43 per cent of control values in the acidic-urine group and 22, 74, and 57 per cent of control values in the alkaline-urine group, respectively. Fractional fluoride clearances (C(F)/C(In)) during anesthesia and operation were 0.06±0.05 in the acidic-urine group (urinary pH 5.08) and 0.68±0.23 in the alkaline-urine group (urinary pH 8.16). Values of total fluoride excretion during the same period were 0.06±0.04 mg and 0.87±0.29 mg, respectively. Mean maximal plasma levels of fluoride were 26.3±7.3 μM in the acidic-urine group and 13.5±2.4 μM in the alkaline-urine group. The differences between groups in fluoride clearance, fluoride excretion, and plasma fluoride levels were all statistically significant. The data clearly show that renal fluoride clearance is closely related to urinary pH.

Original languageEnglish (US)
Pages (from-to)48-52
Number of pages5
JournalAnesthesiology
Volume54
Issue number1
StatePublished - 1981
Externally publishedYes

Fingerprint

Enflurane
Fluorides
Anesthesia
Urine
Renal Elimination
Kidney
Acetazolamide
Inulin

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Renal fluoride excretion and plasma fluoride levels during and after enflurane anesthesia are dependent on urinary pH. / Järnberg, Per-Olof; Ekstrand, J.; Irestedt, L.

In: Anesthesiology, Vol. 54, No. 1, 1981, p. 48-52.

Research output: Contribution to journalArticle

Järnberg, Per-Olof ; Ekstrand, J. ; Irestedt, L. / Renal fluoride excretion and plasma fluoride levels during and after enflurane anesthesia are dependent on urinary pH. In: Anesthesiology. 1981 ; Vol. 54, No. 1. pp. 48-52.
@article{844d64317d5e40699b584b8041305534,
title = "Renal fluoride excretion and plasma fluoride levels during and after enflurane anesthesia are dependent on urinary pH",
abstract = "To determine the effects of urinary pH on fluoride ion excretion and the resulting plasma fluoride concentrations during and after enflurane anesthesia, renal function, plasma inorganic fluoride levels, and fluoride excretion were studied in two groups of patients pretreated with either NH4Cl or acetazolamide to produce acidic or alkaline urine, respectively. During anesthesia, urinary flow rate, inulin clearance (C(In)) and para-aminohippurate (PAH) clearance (C(PAH)) were 7, 61, and 43 per cent of control values in the acidic-urine group and 22, 74, and 57 per cent of control values in the alkaline-urine group, respectively. Fractional fluoride clearances (C(F)/C(In)) during anesthesia and operation were 0.06±0.05 in the acidic-urine group (urinary pH 5.08) and 0.68±0.23 in the alkaline-urine group (urinary pH 8.16). Values of total fluoride excretion during the same period were 0.06±0.04 mg and 0.87±0.29 mg, respectively. Mean maximal plasma levels of fluoride were 26.3±7.3 μM in the acidic-urine group and 13.5±2.4 μM in the alkaline-urine group. The differences between groups in fluoride clearance, fluoride excretion, and plasma fluoride levels were all statistically significant. The data clearly show that renal fluoride clearance is closely related to urinary pH.",
author = "Per-Olof J{\"a}rnberg and J. Ekstrand and L. Irestedt",
year = "1981",
language = "English (US)",
volume = "54",
pages = "48--52",
journal = "Anesthesiology",
issn = "0003-3022",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Renal fluoride excretion and plasma fluoride levels during and after enflurane anesthesia are dependent on urinary pH

AU - Järnberg, Per-Olof

AU - Ekstrand, J.

AU - Irestedt, L.

PY - 1981

Y1 - 1981

N2 - To determine the effects of urinary pH on fluoride ion excretion and the resulting plasma fluoride concentrations during and after enflurane anesthesia, renal function, plasma inorganic fluoride levels, and fluoride excretion were studied in two groups of patients pretreated with either NH4Cl or acetazolamide to produce acidic or alkaline urine, respectively. During anesthesia, urinary flow rate, inulin clearance (C(In)) and para-aminohippurate (PAH) clearance (C(PAH)) were 7, 61, and 43 per cent of control values in the acidic-urine group and 22, 74, and 57 per cent of control values in the alkaline-urine group, respectively. Fractional fluoride clearances (C(F)/C(In)) during anesthesia and operation were 0.06±0.05 in the acidic-urine group (urinary pH 5.08) and 0.68±0.23 in the alkaline-urine group (urinary pH 8.16). Values of total fluoride excretion during the same period were 0.06±0.04 mg and 0.87±0.29 mg, respectively. Mean maximal plasma levels of fluoride were 26.3±7.3 μM in the acidic-urine group and 13.5±2.4 μM in the alkaline-urine group. The differences between groups in fluoride clearance, fluoride excretion, and plasma fluoride levels were all statistically significant. The data clearly show that renal fluoride clearance is closely related to urinary pH.

AB - To determine the effects of urinary pH on fluoride ion excretion and the resulting plasma fluoride concentrations during and after enflurane anesthesia, renal function, plasma inorganic fluoride levels, and fluoride excretion were studied in two groups of patients pretreated with either NH4Cl or acetazolamide to produce acidic or alkaline urine, respectively. During anesthesia, urinary flow rate, inulin clearance (C(In)) and para-aminohippurate (PAH) clearance (C(PAH)) were 7, 61, and 43 per cent of control values in the acidic-urine group and 22, 74, and 57 per cent of control values in the alkaline-urine group, respectively. Fractional fluoride clearances (C(F)/C(In)) during anesthesia and operation were 0.06±0.05 in the acidic-urine group (urinary pH 5.08) and 0.68±0.23 in the alkaline-urine group (urinary pH 8.16). Values of total fluoride excretion during the same period were 0.06±0.04 mg and 0.87±0.29 mg, respectively. Mean maximal plasma levels of fluoride were 26.3±7.3 μM in the acidic-urine group and 13.5±2.4 μM in the alkaline-urine group. The differences between groups in fluoride clearance, fluoride excretion, and plasma fluoride levels were all statistically significant. The data clearly show that renal fluoride clearance is closely related to urinary pH.

UR - http://www.scopus.com/inward/record.url?scp=0019470078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019470078&partnerID=8YFLogxK

M3 - Article

VL - 54

SP - 48

EP - 52

JO - Anesthesiology

JF - Anesthesiology

SN - 0003-3022

IS - 1

ER -