Renal expression of IGF I in hypersomatotropic states

Steven B. Miller, Peter Rotwein, Jonathan D. Bortz, Peter J. Bechtel, Virginia A. Hansen, Sharon A. Rogers, Marc R. Hammerman

Research output: Contribution to journalArticle

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Abstract

We examined in-sulin-like growth factor I (IGF I) gene expression in kidney in two models of hypersomatotropism, rats implanted with GH3 pituitary tumors, and rats administered exogenous growth hormone (GH). Both GH3 tumor-bearing rats and rats administered GH gained weight more rapidly than control animals, and had kidneys that were larger than those of controls. Tumor-bearing rats had increased levels of circulating IGF I. Glomeruli from tumor-implanted rats were sclerotic. Immunostainable IGF I was increased in medullary collecting ducts from tumor-bearing and GH-injected rats compared with kidneys from control animals. Levels of IGF I mRNA in kidneys of rats implanted with GH3 tumors and GH-injected rats were elevated compared with levels in kidneys from controls. Our findings demonstrate enhanced renal IGF I gene expression in hypersomatotropism. Stimulation of renal IGF I synthesis by GH could be causative of changes in renal function and renal size that occur in states of GH excess such as acromegaly.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume259
Issue number2 28-2
StatePublished - 1990
Externally publishedYes

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Intercellular Signaling Peptides and Proteins
Kidney
Growth Hormone
Neoplasms
Gene Expression
Acromegaly
Pituitary Neoplasms
Insulin-Like Growth Factor I
Weights and Measures
Messenger RNA

Keywords

  • Acromegaly
  • Growth hormone
  • Renal hypertrophy

ASJC Scopus subject areas

  • Physiology

Cite this

Miller, S. B., Rotwein, P., Bortz, J. D., Bechtel, P. J., Hansen, V. A., Rogers, S. A., & Hammerman, M. R. (1990). Renal expression of IGF I in hypersomatotropic states. American Journal of Physiology - Renal Fluid and Electrolyte Physiology, 259(2 28-2).

Renal expression of IGF I in hypersomatotropic states. / Miller, Steven B.; Rotwein, Peter; Bortz, Jonathan D.; Bechtel, Peter J.; Hansen, Virginia A.; Rogers, Sharon A.; Hammerman, Marc R.

In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology, Vol. 259, No. 2 28-2, 1990.

Research output: Contribution to journalArticle

Miller, SB, Rotwein, P, Bortz, JD, Bechtel, PJ, Hansen, VA, Rogers, SA & Hammerman, MR 1990, 'Renal expression of IGF I in hypersomatotropic states', American Journal of Physiology - Renal Fluid and Electrolyte Physiology, vol. 259, no. 2 28-2.
Miller SB, Rotwein P, Bortz JD, Bechtel PJ, Hansen VA, Rogers SA et al. Renal expression of IGF I in hypersomatotropic states. American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 1990;259(2 28-2).
Miller, Steven B. ; Rotwein, Peter ; Bortz, Jonathan D. ; Bechtel, Peter J. ; Hansen, Virginia A. ; Rogers, Sharon A. ; Hammerman, Marc R. / Renal expression of IGF I in hypersomatotropic states. In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 1990 ; Vol. 259, No. 2 28-2.
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