Renal expression of IGF I in hypersomatotropic states

S. B. Miller, P. Rotwein, J. D. Bortz, P. J. Bechtel, V. A. Hansen, S. A. Rogers, M. R. Hammerman

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Abstract

We examined insulin-like growth factor I (IGF I) gene expression in kidney in two models of hypersomatotropism, rats implanted with GH3 pituitary tumors, and rats administered exogenous growth hormone (GH). Both GH3 tumor-bearing rats and rats administered GH gained weight more rapidly than control animals, and had kidneys that were larger than those of controls. Tumor-bearing rats had increased levels of circulating IGF I. Glomeruli from tumor-implanted rats were sclerotic. Immunostainable IGF I was increased in medullary collecting ducts from tumor-bearing and GH-injected rats compared with kidneys from control animals. Levels of IGF I mRNA in kidneys of rats implanted with GH3 tumors and GH-injected rats were elevated compared with levels in kidneys from controls. Our findings demonstrate enhanced renal IGF I gene expression in hypersomatotropism. Stimulation of renal IGF I synthesis by GH could be causative of changes in renal function and renal size that occur in states of GH excess such as acromegaly.

Original languageEnglish (US)
Pages (from-to)F251-F257
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume259
Issue number2 28-2
StatePublished - Jan 1 1990

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Keywords

  • acromegaly
  • growth hormone
  • renal hypertrophy

ASJC Scopus subject areas

  • Physiology

Cite this

Miller, S. B., Rotwein, P., Bortz, J. D., Bechtel, P. J., Hansen, V. A., Rogers, S. A., & Hammerman, M. R. (1990). Renal expression of IGF I in hypersomatotropic states. American Journal of Physiology - Renal Fluid and Electrolyte Physiology, 259(2 28-2), F251-F257.