Renal atrophy secondary to chemoradiotherapy of abdominal malignancies

Gary Y. Yang, Kilian Salerno May, Renuka V. Iyer, Rameela Chandrasekhar, Gregory E. Wilding, Susan A. McCloskey, Nikhil I. Khushalani, Saikrishna S. Yendamuri, John F. Gibbs, Marwan Fakih, Charles Thomas

Research output: Contribution to journalArticle

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Abstract

Purpose: To identify factors predictive of renal atrophy after chemoradiotherapy of gastrointestinal malignancies. Methods and Materials: Patients who received chemotherapy and abdominal radiotherapy (RT) between 2002 and 2008 were identified for this study evaluating change in kidney size and function after RT. Imaging and biochemical data were obtained before and after RT in 6-month intervals. Kidney size was defined by craniocaudal measurement on CT images. The primarily irradiated kidney (PK) was defined as the kidney that received the greater mean kidney dose. Receiver operating characteristic (ROC) curves were generated to predict risk for renal atrophy. Results: Of 130 patients, median age was 64 years, and 51.5% were male. Most primary disease sites were pancreas and periampullary tumors (77.7%). Median follow-up was 9.4 months. Creatinine clearance declined 20.89%, and size of the PK decreased 4.67% 1 year after completion of chemoradiation. Compensatory hypertrophy of the non-PK was not seen. Percentage volumes of the PK receiving ≥10 Gy (V 10), 15 Gy (V15), and 20 Gy (V20) were significantly associated with renal atrophy 1 year after RT (p = 0.0030, 0.0029, and 0.0028, respectively). Areas under the ROC curves for V10, V15, and V20 to predict >5% decrease in PK size were 0.760, 0.760, and 0.762, respectively. Conclusions: Significant detriments in PK size and renal function were seen after abdominal RT. The V10, V15, and V20 were predictive of risk for PK atrophy 1 year after RT. Analyses suggest the association of lower-dose renal irradiation with subsequent development of renal atrophy.

Original languageEnglish (US)
Pages (from-to)539-546
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume78
Issue number2
DOIs
StatePublished - Oct 1 2010

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atrophy
kidneys
Chemoradiotherapy
Atrophy
Kidney
radiation therapy
Neoplasms
Radiotherapy
receivers
renal function
creatinine
pancreas
dosage
ROC Curve
clearances
curves
chemotherapy
tumors

Keywords

  • Chemoradiation
  • Complications
  • Dose-volume histogram
  • Kidney tolerance
  • Renal atrophy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research
  • Medicine(all)

Cite this

Renal atrophy secondary to chemoradiotherapy of abdominal malignancies. / Yang, Gary Y.; May, Kilian Salerno; Iyer, Renuka V.; Chandrasekhar, Rameela; Wilding, Gregory E.; McCloskey, Susan A.; Khushalani, Nikhil I.; Yendamuri, Saikrishna S.; Gibbs, John F.; Fakih, Marwan; Thomas, Charles.

In: International Journal of Radiation Oncology Biology Physics, Vol. 78, No. 2, 01.10.2010, p. 539-546.

Research output: Contribution to journalArticle

Yang, GY, May, KS, Iyer, RV, Chandrasekhar, R, Wilding, GE, McCloskey, SA, Khushalani, NI, Yendamuri, SS, Gibbs, JF, Fakih, M & Thomas, C 2010, 'Renal atrophy secondary to chemoradiotherapy of abdominal malignancies', International Journal of Radiation Oncology Biology Physics, vol. 78, no. 2, pp. 539-546. https://doi.org/10.1016/j.ijrobp.2009.07.1744
Yang, Gary Y. ; May, Kilian Salerno ; Iyer, Renuka V. ; Chandrasekhar, Rameela ; Wilding, Gregory E. ; McCloskey, Susan A. ; Khushalani, Nikhil I. ; Yendamuri, Saikrishna S. ; Gibbs, John F. ; Fakih, Marwan ; Thomas, Charles. / Renal atrophy secondary to chemoradiotherapy of abdominal malignancies. In: International Journal of Radiation Oncology Biology Physics. 2010 ; Vol. 78, No. 2. pp. 539-546.
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AU - May, Kilian Salerno

AU - Iyer, Renuka V.

AU - Chandrasekhar, Rameela

AU - Wilding, Gregory E.

AU - McCloskey, Susan A.

AU - Khushalani, Nikhil I.

AU - Yendamuri, Saikrishna S.

AU - Gibbs, John F.

AU - Fakih, Marwan

AU - Thomas, Charles

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N2 - Purpose: To identify factors predictive of renal atrophy after chemoradiotherapy of gastrointestinal malignancies. Methods and Materials: Patients who received chemotherapy and abdominal radiotherapy (RT) between 2002 and 2008 were identified for this study evaluating change in kidney size and function after RT. Imaging and biochemical data were obtained before and after RT in 6-month intervals. Kidney size was defined by craniocaudal measurement on CT images. The primarily irradiated kidney (PK) was defined as the kidney that received the greater mean kidney dose. Receiver operating characteristic (ROC) curves were generated to predict risk for renal atrophy. Results: Of 130 patients, median age was 64 years, and 51.5% were male. Most primary disease sites were pancreas and periampullary tumors (77.7%). Median follow-up was 9.4 months. Creatinine clearance declined 20.89%, and size of the PK decreased 4.67% 1 year after completion of chemoradiation. Compensatory hypertrophy of the non-PK was not seen. Percentage volumes of the PK receiving ≥10 Gy (V 10), 15 Gy (V15), and 20 Gy (V20) were significantly associated with renal atrophy 1 year after RT (p = 0.0030, 0.0029, and 0.0028, respectively). Areas under the ROC curves for V10, V15, and V20 to predict >5% decrease in PK size were 0.760, 0.760, and 0.762, respectively. Conclusions: Significant detriments in PK size and renal function were seen after abdominal RT. The V10, V15, and V20 were predictive of risk for PK atrophy 1 year after RT. Analyses suggest the association of lower-dose renal irradiation with subsequent development of renal atrophy.

AB - Purpose: To identify factors predictive of renal atrophy after chemoradiotherapy of gastrointestinal malignancies. Methods and Materials: Patients who received chemotherapy and abdominal radiotherapy (RT) between 2002 and 2008 were identified for this study evaluating change in kidney size and function after RT. Imaging and biochemical data were obtained before and after RT in 6-month intervals. Kidney size was defined by craniocaudal measurement on CT images. The primarily irradiated kidney (PK) was defined as the kidney that received the greater mean kidney dose. Receiver operating characteristic (ROC) curves were generated to predict risk for renal atrophy. Results: Of 130 patients, median age was 64 years, and 51.5% were male. Most primary disease sites were pancreas and periampullary tumors (77.7%). Median follow-up was 9.4 months. Creatinine clearance declined 20.89%, and size of the PK decreased 4.67% 1 year after completion of chemoradiation. Compensatory hypertrophy of the non-PK was not seen. Percentage volumes of the PK receiving ≥10 Gy (V 10), 15 Gy (V15), and 20 Gy (V20) were significantly associated with renal atrophy 1 year after RT (p = 0.0030, 0.0029, and 0.0028, respectively). Areas under the ROC curves for V10, V15, and V20 to predict >5% decrease in PK size were 0.760, 0.760, and 0.762, respectively. Conclusions: Significant detriments in PK size and renal function were seen after abdominal RT. The V10, V15, and V20 were predictive of risk for PK atrophy 1 year after RT. Analyses suggest the association of lower-dose renal irradiation with subsequent development of renal atrophy.

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KW - Complications

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KW - Kidney tolerance

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