Renal ApoA-1 amyloidosis with Glu34Lys mutation and intra-amyloid lipid accumulation

Nicole Andeen, Daniel Y. Lam, Ian H. De Boer, Roberto F. Nicosia

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Apolipoprotein A-1 (ApoA-1) amyloidosis occurs as a nonhereditary condition in atherosclerotic plaques, but it can also manifest as a hereditary disorder caused by mutations of the APOA1 gene. Hereditary ApoA-1 amyloidosis presents with diverse organ involvement based on the position of the mutation. We describe a case of ApoA-1 amyloidosis with a Glu34Lys mutation; testicular, conjunctival, and renal involvement; and the notable finding of lipid deposition within the amyloid deposits.

Original languageEnglish (US)
Pages (from-to)2703-2705
Number of pages3
JournalJournal of the American Society of Nephrology
Volume25
Issue number12
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Apolipoprotein A-I
Amyloidosis
Amyloid
Kidney
Lipids
Mutation
Amyloid Plaques
Atherosclerotic Plaques
Genes

ASJC Scopus subject areas

  • Nephrology
  • Medicine(all)

Cite this

Renal ApoA-1 amyloidosis with Glu34Lys mutation and intra-amyloid lipid accumulation. / Andeen, Nicole; Lam, Daniel Y.; De Boer, Ian H.; Nicosia, Roberto F.

In: Journal of the American Society of Nephrology, Vol. 25, No. 12, 01.01.2014, p. 2703-2705.

Research output: Contribution to journalArticle

Andeen, Nicole ; Lam, Daniel Y. ; De Boer, Ian H. ; Nicosia, Roberto F. / Renal ApoA-1 amyloidosis with Glu34Lys mutation and intra-amyloid lipid accumulation. In: Journal of the American Society of Nephrology. 2014 ; Vol. 25, No. 12. pp. 2703-2705.
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