Renal ApoA-1 amyloidosis with Glu34Lys mutation and intra-amyloid lipid accumulation

Nicole Andeen, Daniel Y. Lam, Ian H. De Boer, Roberto F. Nicosia

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Apolipoprotein A-1 (ApoA-1) amyloidosis occurs as a nonhereditary condition in atherosclerotic plaques, but it can also manifest as a hereditary disorder caused by mutations of the APOA1 gene. Hereditary ApoA-1 amyloidosis presents with diverse organ involvement based on the position of the mutation. We describe a case of ApoA-1 amyloidosis with a Glu34Lys mutation; testicular, conjunctival, and renal involvement; and the notable finding of lipid deposition within the amyloid deposits.

Original languageEnglish (US)
Pages (from-to)2703-2705
Number of pages3
JournalJournal of the American Society of Nephrology
Volume25
Issue number12
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

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ASJC Scopus subject areas

  • Nephrology
  • Medicine(all)

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