Renal activity of Akt kinase in experimental type 1 diabetes

J. Ždychová, J. Veselá, L. Kazdová, Radko Komers

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14 Scopus citations

Abstract

Akt kinase regulates numerous cell functions including glucose metabolism, cell growth, survival, protein synthesis, and control of local hemodynamics. mTOR is one of down-stream effectors of Akt involved in the initiation of protein translation. However, renal Akt signaling in Type 1 diabetes (DM) in vivo, in particular under the conditions reflecting differences in metabolic control, has received less attention. Renal cortical activity and expression of Akt and mTOR (kinase assay, western blotting) were determined in streptozotocin-diabetic rats (D) with different levels of glycemic control (blood glucose 22.0±1.0, 13.4±1.5, 8.1±0.4 mmol/l, p

Original languageEnglish (US)
Pages (from-to)709-715
Number of pages7
JournalPhysiological Research
Volume57
Issue number5
Publication statusPublished - 2008
Externally publishedYes

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Keywords

  • Akt kinase
  • Diabetic nephropathy
  • Insulin
  • Mammalian target of rapamycin
  • mTOR

ASJC Scopus subject areas

  • Physiology

Cite this

Ždychová, J., Veselá, J., Kazdová, L., & Komers, R. (2008). Renal activity of Akt kinase in experimental type 1 diabetes. Physiological Research, 57(5), 709-715.