Remarkable improvement in adult Leigh syndrome with partial cytochrome c oxidase deficiency

P. C. Goldenberg, R. D. Steiner, L. S. Merkens, T. Dunaway, R. A. Egan, E. A. Zimmerman, Gary Nesbit, B. Robinson, Nancy G. Kennaway

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Abstract

Leigh syndrome (LS) is a heterogeneous disorder, usually due to a defect in oxidative metabolism. Typically, signs and symptoms commence in infancy or childhood, although rare cases of adult onset have been described. Progressive deterioration is the norm. The authors describe a 22-year-old woman with partial cytochrome c oxidase deficiency who developed fulminant LS following an acute febrile illness and who subsequently showed dramatic clinical and neuroradiologic improvement.

Original languageEnglish (US)
Pages (from-to)865-868
Number of pages4
JournalNeurology
Volume60
Issue number5
Publication statusPublished - Mar 11 2003

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Goldenberg, P. C., Steiner, R. D., Merkens, L. S., Dunaway, T., Egan, R. A., Zimmerman, E. A., ... Kennaway, N. G. (2003). Remarkable improvement in adult Leigh syndrome with partial cytochrome c oxidase deficiency. Neurology, 60(5), 865-868.