Remarkable improvement in adult Leigh syndrome with partial cytochrome c oxidase deficiency

P. C. Goldenberg, R. D. Steiner, L. S. Merkens, T. Dunaway, R. A. Egan, E. A. Zimmerman, G. Nesbit, B. Robinson, Nancy G. Kennaway

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28 Scopus citations

Abstract

Leigh syndrome (LS) is a heterogeneous disorder, usually due to a defect in oxidative metabolism. Typically, signs and symptoms commence in infancy or childhood, although rare cases of adult onset have been described. Progressive deterioration is the norm. The authors describe a 22-year-old woman with partial cytochrome c oxidase deficiency who developed fulminant LS following an acute febrile illness and who subsequently showed dramatic clinical and neuroradiologic improvement.

Original languageEnglish (US)
Pages (from-to)865-868
Number of pages4
JournalNeurology
Volume60
Issue number5
DOIs
StatePublished - Mar 11 2003

ASJC Scopus subject areas

  • Clinical Neurology

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    Goldenberg, P. C., Steiner, R. D., Merkens, L. S., Dunaway, T., Egan, R. A., Zimmerman, E. A., Nesbit, G., Robinson, B., & Kennaway, N. G. (2003). Remarkable improvement in adult Leigh syndrome with partial cytochrome c oxidase deficiency. Neurology, 60(5), 865-868. https://doi.org/10.1212/01.WNL.0000049460.72439.7F