Remarkable improvement in adult Leigh syndrome with partial cytochrome c oxidase deficiency

P. C. Goldenberg, R. D. Steiner, L. S. Merkens, T. Dunaway, R. A. Egan, E. A. Zimmerman, Gary Nesbit, B. Robinson, Nancy G. Kennaway

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Leigh syndrome (LS) is a heterogeneous disorder, usually due to a defect in oxidative metabolism. Typically, signs and symptoms commence in infancy or childhood, although rare cases of adult onset have been described. Progressive deterioration is the norm. The authors describe a 22-year-old woman with partial cytochrome c oxidase deficiency who developed fulminant LS following an acute febrile illness and who subsequently showed dramatic clinical and neuroradiologic improvement.

Original languageEnglish (US)
Pages (from-to)865-868
Number of pages4
JournalNeurology
Volume60
Issue number5
StatePublished - Mar 11 2003

Fingerprint

Cytochrome-c Oxidase Deficiency
Leigh Disease
Signs and Symptoms
Fever
Necrotizing Encephalomyelopathy, Subacute, of Leigh, Adult

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Goldenberg, P. C., Steiner, R. D., Merkens, L. S., Dunaway, T., Egan, R. A., Zimmerman, E. A., ... Kennaway, N. G. (2003). Remarkable improvement in adult Leigh syndrome with partial cytochrome c oxidase deficiency. Neurology, 60(5), 865-868.

Remarkable improvement in adult Leigh syndrome with partial cytochrome c oxidase deficiency. / Goldenberg, P. C.; Steiner, R. D.; Merkens, L. S.; Dunaway, T.; Egan, R. A.; Zimmerman, E. A.; Nesbit, Gary; Robinson, B.; Kennaway, Nancy G.

In: Neurology, Vol. 60, No. 5, 11.03.2003, p. 865-868.

Research output: Contribution to journalArticle

Goldenberg, PC, Steiner, RD, Merkens, LS, Dunaway, T, Egan, RA, Zimmerman, EA, Nesbit, G, Robinson, B & Kennaway, NG 2003, 'Remarkable improvement in adult Leigh syndrome with partial cytochrome c oxidase deficiency', Neurology, vol. 60, no. 5, pp. 865-868.
Goldenberg PC, Steiner RD, Merkens LS, Dunaway T, Egan RA, Zimmerman EA et al. Remarkable improvement in adult Leigh syndrome with partial cytochrome c oxidase deficiency. Neurology. 2003 Mar 11;60(5):865-868.
Goldenberg, P. C. ; Steiner, R. D. ; Merkens, L. S. ; Dunaway, T. ; Egan, R. A. ; Zimmerman, E. A. ; Nesbit, Gary ; Robinson, B. ; Kennaway, Nancy G. / Remarkable improvement in adult Leigh syndrome with partial cytochrome c oxidase deficiency. In: Neurology. 2003 ; Vol. 60, No. 5. pp. 865-868.
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