TY - JOUR
T1 - REM sleep and endothermy
T2 - Potential sites and mechanism of a reciprocal interference
AU - Cerri, Matteo
AU - Luppi, Marco
AU - Tupone, Domenico
AU - Zamboni, Giovanni
AU - Amici, Roberto
N1 - Publisher Copyright:
© 2017 Cerri, Luppi, Tupone, Zamboni and Amici.
PY - 2017/8/24
Y1 - 2017/8/24
N2 - Numerous data show a reciprocal interaction between REM sleep and thermoregulation. During REM sleep, the function of thermoregulation appears to be impaired; from the other hand, the tonic activation of thermogenesis, such as during cold exposure, suppresses REM sleep occurrence. Recently, both the central neural network controlling REM sleep and the central neural network controlling thermoregulation have been progressively unraveled. Thermoregulation was shown to be controlled by a central "core" circuit, responsible for the maintenance of body temperature, modulated by a set of accessory areas. REM sleep was suggested to be controlled by a group of hypothalamic neurons overlooking at the REM sleep generating circuits within the brainstem. The two networks overlap in a few areas, and in this review, we will suggest that in such overlap may reside the explanation of the reciprocal interaction between REM sleep and thermoregulation. Considering the peculiar modulation of thermoregulation by REM sleep the result of their coincidental evolution, REM sleep may therefore be seen as a period of transient heterothermy.
AB - Numerous data show a reciprocal interaction between REM sleep and thermoregulation. During REM sleep, the function of thermoregulation appears to be impaired; from the other hand, the tonic activation of thermogenesis, such as during cold exposure, suppresses REM sleep occurrence. Recently, both the central neural network controlling REM sleep and the central neural network controlling thermoregulation have been progressively unraveled. Thermoregulation was shown to be controlled by a central "core" circuit, responsible for the maintenance of body temperature, modulated by a set of accessory areas. REM sleep was suggested to be controlled by a group of hypothalamic neurons overlooking at the REM sleep generating circuits within the brainstem. The two networks overlap in a few areas, and in this review, we will suggest that in such overlap may reside the explanation of the reciprocal interaction between REM sleep and thermoregulation. Considering the peculiar modulation of thermoregulation by REM sleep the result of their coincidental evolution, REM sleep may therefore be seen as a period of transient heterothermy.
KW - Heterothermy
KW - Lateral parabrachial nucleus
KW - Median preoptic nucleus
KW - Melanin concentrating hormone
KW - Orexin
KW - Periaqueductal gray
KW - REM sleep
KW - Thermoregulation
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U2 - 10.3389/fphys.2017.00624
DO - 10.3389/fphys.2017.00624
M3 - Short survey
AN - SCOPUS:85028411045
SN - 1664-042X
VL - 8
JO - Frontiers in Physiology
JF - Frontiers in Physiology
IS - AUG
M1 - 624
ER -