REM sleep and endothermy: Potential sites and mechanism of a reciprocal interference

Matteo Cerri, Marco Luppi, Domenico Tupone, Giovanni Zamboni, Roberto Amici

Research output: Contribution to journalShort survey

7 Citations (Scopus)

Abstract

Numerous data show a reciprocal interaction between REM sleep and thermoregulation. During REM sleep, the function of thermoregulation appears to be impaired; from the other hand, the tonic activation of thermogenesis, such as during cold exposure, suppresses REM sleep occurrence. Recently, both the central neural network controlling REM sleep and the central neural network controlling thermoregulation have been progressively unraveled. Thermoregulation was shown to be controlled by a central "core" circuit, responsible for the maintenance of body temperature, modulated by a set of accessory areas. REM sleep was suggested to be controlled by a group of hypothalamic neurons overlooking at the REM sleep generating circuits within the brainstem. The two networks overlap in a few areas, and in this review, we will suggest that in such overlap may reside the explanation of the reciprocal interaction between REM sleep and thermoregulation. Considering the peculiar modulation of thermoregulation by REM sleep the result of their coincidental evolution, REM sleep may therefore be seen as a period of transient heterothermy.

Original languageEnglish (US)
Article number624
JournalFrontiers in Physiology
Volume8
Issue numberAUG
DOIs
StatePublished - Aug 24 2017
Externally publishedYes

Fingerprint

REM Sleep
Body Temperature Regulation
Thermogenesis
Body Temperature
Brain Stem
Hand
Maintenance
Neurons

Keywords

  • Heterothermy
  • Lateral parabrachial nucleus
  • Median preoptic nucleus
  • Melanin concentrating hormone
  • Orexin
  • Periaqueductal gray
  • REM sleep
  • Thermoregulation

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

REM sleep and endothermy : Potential sites and mechanism of a reciprocal interference. / Cerri, Matteo; Luppi, Marco; Tupone, Domenico; Zamboni, Giovanni; Amici, Roberto.

In: Frontiers in Physiology, Vol. 8, No. AUG, 624, 24.08.2017.

Research output: Contribution to journalShort survey

Cerri, Matteo ; Luppi, Marco ; Tupone, Domenico ; Zamboni, Giovanni ; Amici, Roberto. / REM sleep and endothermy : Potential sites and mechanism of a reciprocal interference. In: Frontiers in Physiology. 2017 ; Vol. 8, No. AUG.
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