Reliability, Validity, and Factor Structure of the Hopkins Symptom Checklist-25

Population-Based Study of Persons Living with HIV in Rural Uganda

Scholastic Ashaba, Bernard Kakuhikire, Dagmar Vořechovská, Jessica M. Perkins, Christine E. Cooper-Vince, Samuel Maling, David Bangsberg, Alexander C. Tsai

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Depression and anxiety are highly comorbid among people living with HIV (PLHIV), but few instruments for screening or measurement have been validated for use in sub-Saharan Africa. The objective of this study was to determine the reliability, validity, and factor structure of the 25-item Hopkins Symptom Checklist (HSCL) in a population-based sample of PLHIV in rural Uganda. This study was nested within an ongoing population-based cohort of all residents living in Nyakabare Parish, Mbarara District, Uganda. All participants who identified as HIV-positive by self-report were included in this analysis. We performed parallel analysis on the scale items and estimated the internal consistency of the identified sub-scales using ordinal alpha. To assess construct validity we correlated the sub-scales with related constructs, including subjective well being (happiness), food insecurity, and health status. Of 1814 eligible adults in the population, 158 (8.7%) self-reported being HIV positive. The mean age was 41 years, and 68% were women. Mean HSCL-25 scores were higher among women compared with men (1.71 vs. 1.44; t = 3.6, P < 0.001). Parallel analysis revealed a three-factor structure that explained 83% of the variance: depression (7 items), anxiety (5 items), and somatic symptoms (7 items). The ordinal alpha statistics for the sub-scales ranged from 0.83 to 0.91. Depending on the sub-scale, between 27 and 41% of the sample met criteria for caseness. Strong evidence of construct validity was shown in the estimated correlations between sub-scale scores and happiness, food insecurity, and self-reported overall health. The HSCL-25 is a reliable and valid measure of mental health among PLHIV in rural Uganda. In cultural contexts where somatic complaints are commonly elicited when screening for symptoms of depression, it may be undesirable to exclude somatic items from depression symptom checklists administered to PLHIV.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalAIDS and Behavior
DOIs
StateAccepted/In press - Jun 30 2017

Fingerprint

Uganda
Checklist
Reproducibility of Results
HIV
Depression
Population
Happiness
Food Supply
Anxiety
Africa South of the Sahara
Self Report
Health Status
Mental Health
Health

Keywords

  • Anxiety
  • Case-finding
  • Depression
  • HIV
  • Screening
  • Sub-Saharan Africa
  • Uganda

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Ashaba, S., Kakuhikire, B., Vořechovská, D., Perkins, J. M., Cooper-Vince, C. E., Maling, S., ... Tsai, A. C. (Accepted/In press). Reliability, Validity, and Factor Structure of the Hopkins Symptom Checklist-25: Population-Based Study of Persons Living with HIV in Rural Uganda. AIDS and Behavior, 1-8. https://doi.org/10.1007/s10461-017-1843-1

Reliability, Validity, and Factor Structure of the Hopkins Symptom Checklist-25 : Population-Based Study of Persons Living with HIV in Rural Uganda. / Ashaba, Scholastic; Kakuhikire, Bernard; Vořechovská, Dagmar; Perkins, Jessica M.; Cooper-Vince, Christine E.; Maling, Samuel; Bangsberg, David; Tsai, Alexander C.

In: AIDS and Behavior, 30.06.2017, p. 1-8.

Research output: Contribution to journalArticle

Ashaba, Scholastic ; Kakuhikire, Bernard ; Vořechovská, Dagmar ; Perkins, Jessica M. ; Cooper-Vince, Christine E. ; Maling, Samuel ; Bangsberg, David ; Tsai, Alexander C. / Reliability, Validity, and Factor Structure of the Hopkins Symptom Checklist-25 : Population-Based Study of Persons Living with HIV in Rural Uganda. In: AIDS and Behavior. 2017 ; pp. 1-8.
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