Reliability of deceased-donor procurement kidney biopsy images uploaded in United Network for Organ Sharing

Sherry G. Mansour, Isaac E. Hall, Peter P. Reese, Yaqi Jia, Heather Thiessen-Philbrook, Gilbert Moeckel, Francis L. Weng, Monica P. Revelo, Mazdak Khalighi, Anshu Trivedi, Mona D. Doshi, Bernd Schröppel, Chirag R. Parikh

Research output: Contribution to journalArticle

Abstract

Prior studies demonstrate poor agreement among pathologists’ interpretation of kidney biopsy slides. Reliability of representative images of these slides uploaded to the United Network of Organ Sharing (UNOS) web portal for clinician review has not been studied. We hypothesized high agreement among pathologists’ image interpretation, since static images eliminate variation induced by viewing different areas of movable slides. To test our hypothesis, we compared the assessments of UNOS-uploaded images recorded in standardized forms by three pathologists. We selected 100 image sets, each having at least two images from kidneys of deceased donors. Weighted Cohen's kappa was used for inter-rater agreement. Mean (SD) donor age was 50 (13). Acute tubular injury had kappas of 0.12, 0.14, and 0.19; arteriolar hyalinosis 0.16, 0.27, and 0.38; interstitial inflammation 0.30, 0.33, and 0.49; interstitial fibrosis 0.28, 0.32, and 0.67; arterial intimal fibrosis 0.34, 0.42, and 0.59; tubular atrophy 0.35, 0.41, and 0.52; glomeruli thrombi 0.32, 0.53, and 0.85; and global glomerulosclerosis 0.68, 0.70, and 0.77. Pathologists’ agreement demonstrated kappas of 0.12 to 0.77. The lower values raise concern about the reliability of using images. Although further research is needed to understand how uploaded images are used clinically, the field may consider higher-quality standards for biopsy photomicrographs.

Original languageEnglish (US)
Article numbere13441
JournalClinical Transplantation
Volume32
Issue number12
DOIs
StatePublished - Dec 1 2018
Externally publishedYes

Fingerprint

Tissue Donors
Kidney
Biopsy
Fibrosis
Tunica Intima
Atrophy
Thrombosis
Inflammation
Pathologists
Wounds and Injuries
Research

Keywords

  • agreement
  • biopsy
  • deceased donor
  • images
  • kappa
  • pathologists
  • renal
  • transplant

ASJC Scopus subject areas

  • Transplantation

Cite this

Mansour, S. G., Hall, I. E., Reese, P. P., Jia, Y., Thiessen-Philbrook, H., Moeckel, G., ... Parikh, C. R. (2018). Reliability of deceased-donor procurement kidney biopsy images uploaded in United Network for Organ Sharing. Clinical Transplantation, 32(12), [e13441]. https://doi.org/10.1111/ctr.13441

Reliability of deceased-donor procurement kidney biopsy images uploaded in United Network for Organ Sharing. / Mansour, Sherry G.; Hall, Isaac E.; Reese, Peter P.; Jia, Yaqi; Thiessen-Philbrook, Heather; Moeckel, Gilbert; Weng, Francis L.; Revelo, Monica P.; Khalighi, Mazdak; Trivedi, Anshu; Doshi, Mona D.; Schröppel, Bernd; Parikh, Chirag R.

In: Clinical Transplantation, Vol. 32, No. 12, e13441, 01.12.2018.

Research output: Contribution to journalArticle

Mansour, SG, Hall, IE, Reese, PP, Jia, Y, Thiessen-Philbrook, H, Moeckel, G, Weng, FL, Revelo, MP, Khalighi, M, Trivedi, A, Doshi, MD, Schröppel, B & Parikh, CR 2018, 'Reliability of deceased-donor procurement kidney biopsy images uploaded in United Network for Organ Sharing', Clinical Transplantation, vol. 32, no. 12, e13441. https://doi.org/10.1111/ctr.13441
Mansour, Sherry G. ; Hall, Isaac E. ; Reese, Peter P. ; Jia, Yaqi ; Thiessen-Philbrook, Heather ; Moeckel, Gilbert ; Weng, Francis L. ; Revelo, Monica P. ; Khalighi, Mazdak ; Trivedi, Anshu ; Doshi, Mona D. ; Schröppel, Bernd ; Parikh, Chirag R. / Reliability of deceased-donor procurement kidney biopsy images uploaded in United Network for Organ Sharing. In: Clinical Transplantation. 2018 ; Vol. 32, No. 12.
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abstract = "Prior studies demonstrate poor agreement among pathologists’ interpretation of kidney biopsy slides. Reliability of representative images of these slides uploaded to the United Network of Organ Sharing (UNOS) web portal for clinician review has not been studied. We hypothesized high agreement among pathologists’ image interpretation, since static images eliminate variation induced by viewing different areas of movable slides. To test our hypothesis, we compared the assessments of UNOS-uploaded images recorded in standardized forms by three pathologists. We selected 100 image sets, each having at least two images from kidneys of deceased donors. Weighted Cohen's kappa was used for inter-rater agreement. Mean (SD) donor age was 50 (13). Acute tubular injury had kappas of 0.12, 0.14, and 0.19; arteriolar hyalinosis 0.16, 0.27, and 0.38; interstitial inflammation 0.30, 0.33, and 0.49; interstitial fibrosis 0.28, 0.32, and 0.67; arterial intimal fibrosis 0.34, 0.42, and 0.59; tubular atrophy 0.35, 0.41, and 0.52; glomeruli thrombi 0.32, 0.53, and 0.85; and global glomerulosclerosis 0.68, 0.70, and 0.77. Pathologists’ agreement demonstrated kappas of 0.12 to 0.77. The lower values raise concern about the reliability of using images. Although further research is needed to understand how uploaded images are used clinically, the field may consider higher-quality standards for biopsy photomicrographs.",
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