Relative shift in activity from medial to lateral frontal cortex during internally versus externally guided word generation

Bruce Crosson, Joseph R. Sadek, Leeza Maron, Didem Gökçay, Cecile M. Mohr, Edward J. Auerbach, Alan J. Freeman, Christiana M. Leonard, Richard W. Briggs

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Goldberg (1985) hypothesized that as language output changes from internally to externally guided production, activity shifts from supplementary motor area (SMA) to lateral premotor areas, including Broca's area. To nest this hypothesis, 15 right-handed native English speakers performed three word generation tasks varying in the amount of internal guidance and a repetition task during functional magnetic resonance imaging (fMRI). Volumes of significant activity for each task versus a resting state were derived using voxel-by-voxel repeated-measures t tests (p <.001) across subjects. Changes in the size of activity volumes for left medial frontal regions (SMA and pre-SMA/BA 32) versus left lateral frontal regions (Broca's area, inferior frontal sulcus) were assessed as internal guidance of word generation decreased and external guidance increased. Comparing SMA to Broca's area, Goldberg's hypothesis was not verified. However, pre-SMA/BA 32 activity volumes decreased significantly and inferior frontal sulcus activity volumes increased significantly as word generation tasks moved from internally to externally guided.

Original languageEnglish (US)
Pages (from-to)272-283
Number of pages12
JournalJournal of Cognitive Neuroscience
Volume13
Issue number2
DOIs
StatePublished - Feb 15 2001
Externally publishedYes

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Motor Cortex
Frontal Lobe
Prefrontal Cortex
Language
Magnetic Resonance Imaging
Broca Area

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

Cite this

Relative shift in activity from medial to lateral frontal cortex during internally versus externally guided word generation. / Crosson, Bruce; Sadek, Joseph R.; Maron, Leeza; Gökçay, Didem; Mohr, Cecile M.; Auerbach, Edward J.; Freeman, Alan J.; Leonard, Christiana M.; Briggs, Richard W.

In: Journal of Cognitive Neuroscience, Vol. 13, No. 2, 15.02.2001, p. 272-283.

Research output: Contribution to journalArticle

Crosson, B, Sadek, JR, Maron, L, Gökçay, D, Mohr, CM, Auerbach, EJ, Freeman, AJ, Leonard, CM & Briggs, RW 2001, 'Relative shift in activity from medial to lateral frontal cortex during internally versus externally guided word generation', Journal of Cognitive Neuroscience, vol. 13, no. 2, pp. 272-283. https://doi.org/10.1162/089892901564225
Crosson, Bruce ; Sadek, Joseph R. ; Maron, Leeza ; Gökçay, Didem ; Mohr, Cecile M. ; Auerbach, Edward J. ; Freeman, Alan J. ; Leonard, Christiana M. ; Briggs, Richard W. / Relative shift in activity from medial to lateral frontal cortex during internally versus externally guided word generation. In: Journal of Cognitive Neuroscience. 2001 ; Vol. 13, No. 2. pp. 272-283.
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