Relative adrenal insufficiency

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: This article will review the clinical presentation, diagnosis, and treatment of acute adrenal insufficiency and explore the concept of 'relative adrenal insufficiency' in the critically ill. RECENT FINDINGS: Current dogma suggests that as many as 70% of patients in intensive care units with the clinical syndromes of sepsis or cardiogenic shock have 'relative adrenal insufficiency'. This article will explore how this concept came into being and why the concept has no clinical utility. SUMMARY: This article will provide an approach to critically ill patients that will identify adrenal insufficiency when it is part of the pathophysiology of a given patient and, at the same time, prevent the unnecessary treatment of critically ill patients with high doses of glucocorticoids for 'stress' when adrenal insufficiency is not a factor in the illness.

Original languageEnglish (US)
Pages (from-to)392-400
Number of pages9
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Volume16
Issue number5
DOIs
StatePublished - Oct 2009

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Adrenal Insufficiency
Critical Illness
Systemic Inflammatory Response Syndrome
Cardiogenic Shock
Glucocorticoids
Intensive Care Units
Therapeutics

Keywords

  • Cortrosyn stimulation test
  • Plasma-free cortisol
  • Relative adrenal insufficiency

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Nutrition and Dietetics

Cite this

Relative adrenal insufficiency. / Loriaux, Donald (Lynn); Fleseriu, Maria.

In: Current Opinion in Endocrinology, Diabetes and Obesity, Vol. 16, No. 5, 10.2009, p. 392-400.

Research output: Contribution to journalArticle

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