Relationships among delay of diagnosis, extent of disease, and survival in patients with abdominal carcinoid tumors

SuEllen Toth-Fejel, Rodney Pommier

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    Abstract

    Background A correlation between delay in diagnosis of carcinoid and extent of disease and survival was investigated. Methods In all, 115 patients with carcinoid were interviewed. Data collected included symptoms, delay of diagnosis, incorrect diagnoses given, extent of disease at diagnosis, and survival. Delay in diagnosis and extent of disease were correlated by regression analysis and the impact on death by Fisher's exact test. Results Mean delay was 66 months. There was no correlation between delay in diagnosis and extent of disease (R = 0.119, R2 = 0.014, P = 0.20) or death. However, patients with disease beyond lymph nodes were significantly more likely to die (P = 0.005). Conclusions Delays of diagnosis of carcinoid are common but do not impact extent of disease or survival. Extent of disease at diagnosis does impact survival, but is not mitigated by early diagnosis, indicating that outcome is dictated by the biology of the disease.

    Original languageEnglish (US)
    Pages (from-to)575-579
    Number of pages5
    JournalAmerican Journal of Surgery
    Volume187
    Issue number5
    DOIs
    StatePublished - May 2004

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    Carcinoid Tumor
    Survival
    Early Diagnosis
    Lymph Nodes
    Regression Analysis

    Keywords

    • Carcinoid
    • Delayed diagnosis

    ASJC Scopus subject areas

    • Surgery

    Cite this

    Relationships among delay of diagnosis, extent of disease, and survival in patients with abdominal carcinoid tumors. / Toth-Fejel, SuEllen; Pommier, Rodney.

    In: American Journal of Surgery, Vol. 187, No. 5, 05.2004, p. 575-579.

    Research output: Contribution to journalArticle

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    N2 - Background A correlation between delay in diagnosis of carcinoid and extent of disease and survival was investigated. Methods In all, 115 patients with carcinoid were interviewed. Data collected included symptoms, delay of diagnosis, incorrect diagnoses given, extent of disease at diagnosis, and survival. Delay in diagnosis and extent of disease were correlated by regression analysis and the impact on death by Fisher's exact test. Results Mean delay was 66 months. There was no correlation between delay in diagnosis and extent of disease (R = 0.119, R2 = 0.014, P = 0.20) or death. However, patients with disease beyond lymph nodes were significantly more likely to die (P = 0.005). Conclusions Delays of diagnosis of carcinoid are common but do not impact extent of disease or survival. Extent of disease at diagnosis does impact survival, but is not mitigated by early diagnosis, indicating that outcome is dictated by the biology of the disease.

    AB - Background A correlation between delay in diagnosis of carcinoid and extent of disease and survival was investigated. Methods In all, 115 patients with carcinoid were interviewed. Data collected included symptoms, delay of diagnosis, incorrect diagnoses given, extent of disease at diagnosis, and survival. Delay in diagnosis and extent of disease were correlated by regression analysis and the impact on death by Fisher's exact test. Results Mean delay was 66 months. There was no correlation between delay in diagnosis and extent of disease (R = 0.119, R2 = 0.014, P = 0.20) or death. However, patients with disease beyond lymph nodes were significantly more likely to die (P = 0.005). Conclusions Delays of diagnosis of carcinoid are common but do not impact extent of disease or survival. Extent of disease at diagnosis does impact survival, but is not mitigated by early diagnosis, indicating that outcome is dictated by the biology of the disease.

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