Relationship of oral disease to the presence of cytomegalovirus DNA in the saliva of AIDS patients

Martin S. Greenberg, Gary Dubin, Jeffery C.B. Stewart, Christopher G. Cumming, Rob Roy MacGregor, Harvey M. Friedman

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Cytomegalovirus is an important pathogen in persons infected with human immunodeficiency virus. In this study a thorough oral examination was done and blood and urine cultures for cytomegalovirus were obtained from a group of 31 patients with acquired immunodeficiency syndrome with CD4 lymphocyte counts less than 150 cells/mm3. Whole saliva was also collected for detection of cytomegalovirus deoxyribonucleic acid (DNA) via the polymerase chain reaction. The presence of cytomegalovirus DNA in the saliva specimens was not related to the presence of cytomegalovirus in the urine, which suggests a local source of cytomegalovirus from salivary gland and kidney parenchyma. There was also a strong statistical relationship between salivary cytomegalovirus DNA and xerostomia (p=0.0004), which suggests that cytomegalovirus may be a cause of salivary gland dysfunction in patients with acquired immunodeficiency syndrome with low CD4 counts.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and
Volume79
Issue number2
DOIs
StatePublished - Feb 1995

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ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

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