Relationship of muscle capillary basement membrane thickness and diabetic retinopathy

Robert Klein, K. R. Feingold, C. Morgan, W. H. Stern, M. D. Siperstein

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We examined the relationship between the thickness of the quadriceps muscle capillary basement membrane and diabetic retinopathy. Basement membrane thickness was measured in two groups of patients with long-standing type II diabetes mellitus. One group of patients (N = 13) had no evidence of diabetic retinopathy on fluorescein angiography, whereas the other (N = 12) had proliferative microvascular disease. All the patients were male, and both groups were of similar ages, duration of diabetes, serum creatinines, and glycemic control as reflected by HbA1 levels. Mean muscle capillary basement membrane width (± SE) of the patients with proliferative retinopathy (3346 ± 262) was significantly greater (P <.05) than that observed in the patients without retinopathy (2660 ± 177). The results of this study suggest that there is a relationship between capillary basement membrane thickness in skeletal muscle and the severity of microangiopathy in the eye. However, there was a substantial overlap between the two groups, indicating that for any individual patient the measurement of muscle capillary basement width will probably not be useful in identifying the presence or absence of retinopathy.

Original languageEnglish (US)
Pages (from-to)195-199
Number of pages5
JournalDiabetes Care
Volume10
Issue number2
StatePublished - 1987
Externally publishedYes

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Diabetic Retinopathy
Basement Membrane
Muscles
Fluorescein Angiography
Quadriceps Muscle
Glycosylated Hemoglobin A
Type 2 Diabetes Mellitus
Creatinine
Skeletal Muscle
Serum

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Klein, R., Feingold, K. R., Morgan, C., Stern, W. H., & Siperstein, M. D. (1987). Relationship of muscle capillary basement membrane thickness and diabetic retinopathy. Diabetes Care, 10(2), 195-199.

Relationship of muscle capillary basement membrane thickness and diabetic retinopathy. / Klein, Robert; Feingold, K. R.; Morgan, C.; Stern, W. H.; Siperstein, M. D.

In: Diabetes Care, Vol. 10, No. 2, 1987, p. 195-199.

Research output: Contribution to journalArticle

Klein, R, Feingold, KR, Morgan, C, Stern, WH & Siperstein, MD 1987, 'Relationship of muscle capillary basement membrane thickness and diabetic retinopathy', Diabetes Care, vol. 10, no. 2, pp. 195-199.
Klein R, Feingold KR, Morgan C, Stern WH, Siperstein MD. Relationship of muscle capillary basement membrane thickness and diabetic retinopathy. Diabetes Care. 1987;10(2):195-199.
Klein, Robert ; Feingold, K. R. ; Morgan, C. ; Stern, W. H. ; Siperstein, M. D. / Relationship of muscle capillary basement membrane thickness and diabetic retinopathy. In: Diabetes Care. 1987 ; Vol. 10, No. 2. pp. 195-199.
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