Relationship of mineral metabolism and long-term calcium and cholecalciferol supplementation to blood pressure in normotensive men

Eric Orwoll, Shelia Oviatt

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

To better understand the effects of calcium and cholecalciferol supplementation on blood pressure, we examined systolic and diastolic blood pressures in 65 men treated with 1000 mg Ca/d and 1000 IU cholecalciferol/d or placebo for 3 y. Subjects were normotensive and had no medical condition and took no medication known to affect mineral metabolism or blood pressure. At baseline, systolic blood pressure was positively related to fasting calcium excretion and negatively to ionized calcium concentrations. Phosphorus concentrations (negatively) and fasting calcium excretion (positively) were correlated with diastolic pressures. Nevertheless, calcium and cholecalciferol supplementation did not influence blood pressure at any time during the study. These results suggest that whereas calcium metabolism may be related to the control of blood pressure, dietary calcium and cholecalciferol intakes do not play a major role in its regulation in normotensive individuals. Calcium and cholecalciferol supplements should not be expected to have an effect on blood pressure in normotensive populations.

Original languageEnglish (US)
Pages (from-to)717-721
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume52
Issue number4
StatePublished - Oct 1990
Externally publishedYes

Fingerprint

mineral metabolism
cholecalciferol
Cholecalciferol
blood pressure
Minerals
Blood Pressure
Calcium
calcium
systolic blood pressure
fasting
excretion
Fasting
diastolic blood pressure
Dietary Calcium
drug therapy
placebos
Phosphorus
phosphorus
metabolism
Placebos

Keywords

  • Blood pressure
  • Calcium supplementation
  • Vitamin D supplementation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

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