Relationship of family history of type 2 diabetes, hypoglycemia, and autoantibodies to weight gain and lipids with intensive and conventional therapy in the diabetes control and complications trial

Jonathan Purnell, Raj K. Dev, Michael W. Steffes, Patricia A. Cleary, Jerry P. Palmer, Irl B. Hirsch, John E. Hokanson, John D. Brunzell

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Intensive therapy for type 1 diabetes results in greater weight gain than conventional therapy. Many factors may predispose to this greater weight gain, including improved glycemic control, genetic susceptibility to obesity, and hypoglycemia. To study this, relationships among family history of type 2 diabetes, frequency of severe hypoglycemia, β-cell autoantibodies, and weight gain were examined in 1,168 subjects aged ≥18 years at baseline randomized to intensive and conventional therapy groups in the Diabetes Control and Complications Trial. With intensive therapy, subjects with a family history of type 2 diabetes had greater central weight gain and dyslipidemia characterized by higher triglyceride levels and greater cholesterol in VLDLs and intermediate-density lipoproteins compared with subjects with no family history. Neither the frequency of severe hypoglycemia nor positivity to GAD65 and insulinoma-associated protein 2 antibodies was associated with increased weight gain with either intensive or conventional therapy. These data support the hypothesis that increased weight gain with intensive therapy might be explained, in part, by genetic traits.

Original languageEnglish (US)
Pages (from-to)2623-2629
Number of pages7
JournalDiabetes
Volume52
Issue number10
DOIs
StatePublished - Oct 1 2003

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Diabetes Complications
Hypoglycemia
Autoantibodies
Type 2 Diabetes Mellitus
Weight Gain
Lipids
Class 8 Receptor-Like Protein Tyrosine Phosphatases
Therapeutics
IDL Lipoproteins
VLDL Cholesterol
Genetic Predisposition to Disease
Dyslipidemias
Group Psychotherapy
Type 1 Diabetes Mellitus
Triglycerides
Obesity
Antibodies

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Relationship of family history of type 2 diabetes, hypoglycemia, and autoantibodies to weight gain and lipids with intensive and conventional therapy in the diabetes control and complications trial. / Purnell, Jonathan; Dev, Raj K.; Steffes, Michael W.; Cleary, Patricia A.; Palmer, Jerry P.; Hirsch, Irl B.; Hokanson, John E.; Brunzell, John D.

In: Diabetes, Vol. 52, No. 10, 01.10.2003, p. 2623-2629.

Research output: Contribution to journalArticle

Purnell, Jonathan ; Dev, Raj K. ; Steffes, Michael W. ; Cleary, Patricia A. ; Palmer, Jerry P. ; Hirsch, Irl B. ; Hokanson, John E. ; Brunzell, John D. / Relationship of family history of type 2 diabetes, hypoglycemia, and autoantibodies to weight gain and lipids with intensive and conventional therapy in the diabetes control and complications trial. In: Diabetes. 2003 ; Vol. 52, No. 10. pp. 2623-2629.
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