Relationship of antioxidant enzymes to trace metals in premature infants

R. K. Huston, T. R. Shearer, B. J. Jelen, P. D. Whall, J. W. Reynolds

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Serum levels of the trace metals copper, zinc, and selenium were measured in premature infants. White blood cell glutathione peroxidase and superoxide dismutase levels were measured in conjunction with the trace metals. Three groups of infants were evaluated: group I was relatively healthy, group II were infants with stage 2 bronchopulmonary dysplasia (BPD) or less, group III were infants with stage 3 BPD or worse. Zinc and selenium levels declined in all groups during conventional parenteral nutirition (TPN) regimens, while copper remained stable. Copper did decline in groups I and II coincident with an acceleration in growth rate. An expected rise in antioxidant enzyme levels in infants with pulmonary oxygen toxicity was not seen. This study suggests that supplemental selenium as well as an increased zinc intake over current recommendations for premature infants receiving TPN may be indicated.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalJournal of Parenteral and Enteral Nutrition
Issue number2
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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