Relationship between T lymphocyte subsets and cortisol in systemic lupus erythematosus

D. Shah, R. Kiran, A. Wanchu, Archana Bhatnagar

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background: Systemic Lupus Erythematosus (SLE) is a complex chronic immunological disease characterized by increased B cell activity and altered T cell function. Objective: To investigate relationship between T lymphocyte subsets and cortisol with the disease activity of systemic lupus erythematosus patients in North India. Materials and methods: The percentage of CD4 + and CD8+ T cells in the lymphocyte of SLE patients and healthy controls were determined by fl ow cytometry. Serum cortisol of SLE patients and healthy controls was determined by enzyme-linked immunosorbent assay (ELISA). Results: A significant decrease in the percentage of CD4 + T cells and increase in the percentage of CD8+ T cells were found in patients with SLE compared to the healthy controls. Decrease in the ratio of CD4+/CD8+ T cell and low level of serum cortisol were found in the patients with SLE. The ratio of CD4 +/CD8+ T cell was inversely correlated with systemic lupus erythematosus disease activity index (SLEDAI) score and erythrocyte sedimentation rate (ESR). A positive correlation was observed between CD8 + T cells and SLEDAI score. Furthermore, CD8+ T cells were positively correlated with ESR in the patients with SLE. Conclusion: The results showed that low level of cortisol and high percentage of CD8+ T cells in the lymphocytes could be actively involved in the pathogenesis of SLE.

Original languageEnglish (US)
Pages (from-to)213-219
Number of pages7
JournalKathmandu University Medical Journal
Volume7
Issue number27
DOIs
StatePublished - Jan 1 2009

Keywords

  • CD4/CD8 T cell ratio
  • Cortisol
  • Systemic lupus erythematosus
  • T-cell activation

ASJC Scopus subject areas

  • Medicine(all)

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