Relationship between retinal perfusion and retinal thickness in healthy subjects: An optical coherence tomography angiography study

Jian Yu, Ruiping Gu, Yuan Zong, Huan Xu, Xiaolei Wang, Xinghuai Sun, Chunhui Jiang, Bing Xie, Jia Yali, David Huang

Research output: Contribution to journalArticle

37 Scopus citations


PURPOSE. To investigate the relationship between retinal perfusion and retinal thickness in the peripapillary and macular areas of healthy subjects. METHODS. Using spectral-domain optic coherence tomography and split-spectrum amplitude decorrelation angiography (SSADA) algorithm, retinal perfusion and retinal thicknesses in the macular and peripapillary areas were measured in healthy volunteers, and correlations among these variables were analyzed. RESULTS. Overall, 64 subjects (121 eyes) including 28 males and 36 females with a mean ± SD age of 38 ± 13 years participated. Linear mixed-models showed that vessel area density was significantly correlated with the inner retinal thickness (from the inner limiting membrane to the outer border of the inner nucleus layer; P <0.05), but not with the thickness of the full retina (P > 0.05) in the parafoveal area. The area of the foveal capillary-free zone was negatively correlated with the inner and full foveal thicknesses (all P <0.001). In the peripapillary area, the vessel area density was positively correlated with the thickness of the retinal nerve fiber layer (P <0.001). CONCLUSIONS. In healthy subjects, retinal perfusion in small vessels was closely correlated with the thickness of the inner retinal layers in both the macular and peripapillary areas.

Original languageEnglish (US)
Pages (from-to)OCT204-OCT210
JournalInvestigative Ophthalmology and Visual Science
Issue number9
StatePublished - Jul 1 2016



  • Capillary-free zone (CFZ)
  • Macular perfusion
  • Optical coherence tomography (OCT) angiogram
  • Retinal thickness
  • Split-spectrum amplitude decorrelation angiography (SSADA) algorithm

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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