Relationship between membrane properties and cell size of developing rat genioglossal motoneurons studied in vitro

P. A. Núñez-Abades; W. E. Cameron

doi:10.1016/S0304-3940(97)13398-5

Relationship between membrane properties and cell size of developing rat genioglossal motoneurons studied in vitro

P. A. Núñez-Abades, W. E. Cameron

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Abstract

Electrical properties and morphology of 21 genioglossal motoneurons were measured in a slice preparation of the rat brainstem at four different postnatal ages. The motoneurons labeled with neurobiotin were reconstructed and quantified in three-dimensional space. There was no strong correlation found between the input resistance or membrane time constant and the total membrane surface area. We conclude that there is no electrical property of these developing motoneurons that can accurately predict their anatomical size.

Original language	English (US)
Pages (from-to)	41-44
Number of pages	4
Journal	Neuroscience Letters
Volume	223
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(97)13398-5
State	Published - Feb 14 1997

Keywords

Brainstem
Genioglossus
Hypoglossal nucleus
Postnatal development
Respiration
Three-dimensional reconstruction
Tongue
Upper airways

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(97)13398-5

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title = "Relationship between membrane properties and cell size of developing rat genioglossal motoneurons studied in vitro",

abstract = "Electrical properties and morphology of 21 genioglossal motoneurons were measured in a slice preparation of the rat brainstem at four different postnatal ages. The motoneurons labeled with neurobiotin were reconstructed and quantified in three-dimensional space. There was no strong correlation found between the input resistance or membrane time constant and the total membrane surface area. We conclude that there is no electrical property of these developing motoneurons that can accurately predict their anatomical size.",

keywords = "Brainstem, Genioglossus, Hypoglossal nucleus, Postnatal development, Respiration, Three-dimensional reconstruction, Tongue, Upper airways",

author = "N{\'u}{\~n}ez-Abades, {P. A.} and Cameron, {W. E.}",

note = "Funding Information: The authors thank Mr. Fang He for his technical assistance in reconstructing the motoneurons with the Eutectic Neuron Tracing System. This work was supported by a grant from NIH (HD 22703). Dr. Pedro A. N{\'u}{\~n}ez-Abades was supported by a postdoctoral fellowship from the Ministerio de Educaci{\'o}n y Ciencia, Spain. ",

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AU - Cameron, W. E.

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N2 - Electrical properties and morphology of 21 genioglossal motoneurons were measured in a slice preparation of the rat brainstem at four different postnatal ages. The motoneurons labeled with neurobiotin were reconstructed and quantified in three-dimensional space. There was no strong correlation found between the input resistance or membrane time constant and the total membrane surface area. We conclude that there is no electrical property of these developing motoneurons that can accurately predict their anatomical size.

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KW - Brainstem

KW - Genioglossus

KW - Hypoglossal nucleus

KW - Postnatal development

KW - Respiration

KW - Three-dimensional reconstruction

KW - Tongue

KW - Upper airways

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Relationship between membrane properties and cell size of developing rat genioglossal motoneurons studied in vitro

Abstract

Keywords

ASJC Scopus subject areas

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