Relationship between maldistribution of ventilation and airways obstruction in children with asthma

Michael Wall, Mary C. Misley, Arthur C. Brown, William M. Vollmer, A (Sonia) Buist

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

This study was designed to explore the relationship between ventilation non-uniformity, as assessed by moment analysis of nitrogen washout, and airways obstruction, as assessed by spirometry, in children with asthma. Moment ratios derived fromt the multibreath washout curves in asthmatics were significantly higher than those obtained from healthy controls (P1 were paralleled by corresponding significant changes in moment ratios with a sensitivity of approximately 81% and a specificity of 82%. Additionally, changes in FEV1 induced by an inhaled bronchodilator were associated with concomitant changes in moment ratios. We conclude that: (1) the majority of children with asthma have some degree of ventilation non-uniformity which is correlated with their degree of airways obstruction, and (2) spontaneous changes in airways obstruction in such subjects are paralleled by changes in ventilation non-uniformity.

Original languageEnglish (US)
Pages (from-to)287-297
Number of pages11
JournalRespiration Physiology
Volume69
Issue number3
DOIs
StatePublished - 1987

Fingerprint

Airway Obstruction
Ventilation
Asthma
Bronchodilator Agents
Spirometry
Nitrogen

Keywords

  • Airways obstruction
  • Asthma
  • Distribution of ventilation
  • Nitrogen washout

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Relationship between maldistribution of ventilation and airways obstruction in children with asthma. / Wall, Michael; Misley, Mary C.; Brown, Arthur C.; Vollmer, William M.; Buist, A (Sonia).

In: Respiration Physiology, Vol. 69, No. 3, 1987, p. 287-297.

Research output: Contribution to journalArticle

Wall, Michael ; Misley, Mary C. ; Brown, Arthur C. ; Vollmer, William M. ; Buist, A (Sonia). / Relationship between maldistribution of ventilation and airways obstruction in children with asthma. In: Respiration Physiology. 1987 ; Vol. 69, No. 3. pp. 287-297.
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