Relationship between left ventricular systolic function and plasma clearance of 169Yb-DTPA in normal and ischemic dogs

Sanjiv Kaul, D. D. Watson, J. D. Oliner, R. D. Okada, A. E. Weyman, H. W. Strauss

Research output: Contribution to journalArticle

Abstract

Plasma clearance of 169Yb-DTPA, a heavy chelate metal excreted only by glomerular filtration, was measured serially in a canine model to determine whether the clearance of this substance correlates with left ventricular systolic function. Fourteen anesthetized open-chest dogs were studied. Six dogs (group I) were used to estimate the clearance of 169Yb-DTPA in the setting of normal left ventricular function. Eight dogs (group II) were used to estimate clearance of 169Yb-DTPA in the presence of ischemic left ventricular dysfunction. Cardiac output, mean arterial pressure, and plasma levels of 169Yb-DTPA were measured serially. In group II dogs, area at risk for necrosis was defined using myocardial contrast echocardiography. The change in clearance of 169Yb-DTPA in group II dogs correlated well with change in cardiac output and area at risk (rc = 0.80 and -0.93, respectively) and was significantly different from group I dogs (p <0.01). However, changes in clearance of 169Yb-DTPA in the group II dogs did not correlate well with change in mean arterial pressure (r = 0.26). In conclusion: (1) clearance of 169Yb-DTPA is constant over time in the absence of ischemic left ventricular dysfunction and derangement of other hemodynamic parameters; (2) changes in clearance of 169Yb-DTPA correlate well with changes in systolic pump function and left ventricular area at risk in the setting of ischemic left ventricular dysfunction, and (3) clearance of 169Yb-DTPA is not related to mean arterial pressure.

Original languageEnglish (US)
Pages (from-to)144-149
Number of pages6
JournalNephron
Volume47
Issue number2
StatePublished - 1987
Externally publishedYes

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Pentetic Acid
Left Ventricular Function
Dogs
Left Ventricular Dysfunction
Arterial Pressure
Cardiac Output
Heavy Metals
Echocardiography
Canidae
Necrosis
Thorax
Hemodynamics

ASJC Scopus subject areas

  • Nephrology

Cite this

Kaul, S., Watson, D. D., Oliner, J. D., Okada, R. D., Weyman, A. E., & Strauss, H. W. (1987). Relationship between left ventricular systolic function and plasma clearance of 169Yb-DTPA in normal and ischemic dogs. Nephron, 47(2), 144-149.

Relationship between left ventricular systolic function and plasma clearance of 169Yb-DTPA in normal and ischemic dogs. / Kaul, Sanjiv; Watson, D. D.; Oliner, J. D.; Okada, R. D.; Weyman, A. E.; Strauss, H. W.

In: Nephron, Vol. 47, No. 2, 1987, p. 144-149.

Research output: Contribution to journalArticle

Kaul, S, Watson, DD, Oliner, JD, Okada, RD, Weyman, AE & Strauss, HW 1987, 'Relationship between left ventricular systolic function and plasma clearance of 169Yb-DTPA in normal and ischemic dogs', Nephron, vol. 47, no. 2, pp. 144-149.
Kaul, Sanjiv ; Watson, D. D. ; Oliner, J. D. ; Okada, R. D. ; Weyman, A. E. ; Strauss, H. W. / Relationship between left ventricular systolic function and plasma clearance of 169Yb-DTPA in normal and ischemic dogs. In: Nephron. 1987 ; Vol. 47, No. 2. pp. 144-149.
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