Relationship between fatigue, sleep quality and inflammatory cytokines during external beam radiation therapy for prostate cancer

A prospective study

Emma B. Holliday, Nathan Dieckmann, Tasha L. McDonald, Arthur Hung, Charles Thomas, Lisa Wood

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background and purpose Mechanisms of fatigue reported during radiotherapy are poorly defined but may include inflammatory cytokines and/or sleep disturbances. This prospective, longitudinal, phase II study assessed fatigue, sleep, and serum cytokine levels during radiotherapy for early-stage prostate cancer (PCa). Material and methods Twenty-eight men undergoing radiotherapy for early-stage PCa wore an Actiwatch Score to record fatigue level, sleep time, onset latency, efficiency and wake after sleep onset. Serum levels of IL-1α, IL-1β, TNF-α, IL-6, IL-8, IL-10 and VEGF were measured weekly during radiotherapy. Patient reported quality of life (QOL) metrics were collected before and after treatment. Linear mixed effects models examined trajectories across treatment weeks. Results Fatigue increased across treatment weeks (P

Original languageEnglish (US)
Pages (from-to)105-111
Number of pages7
JournalRadiotherapy and Oncology
Volume118
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Fatigue
Prostatic Neoplasms
Sleep
Radiotherapy
Prospective Studies
Cytokines
Interleukin-1
Serum
Interleukin-8
Interleukin-10
Vascular Endothelial Growth Factor A
Interleukin-6
Therapeutics
Quality of Life

Keywords

  • Cancer treatment related fatigue
  • Cytokines
  • Prosate Cancer
  • Radiotherapy
  • Sleep disturbance

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology

Cite this

Relationship between fatigue, sleep quality and inflammatory cytokines during external beam radiation therapy for prostate cancer : A prospective study. / Holliday, Emma B.; Dieckmann, Nathan; McDonald, Tasha L.; Hung, Arthur; Thomas, Charles; Wood, Lisa.

In: Radiotherapy and Oncology, Vol. 118, No. 1, 01.01.2016, p. 105-111.

Research output: Contribution to journalArticle

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