Relationship between fatigue, sleep quality and inflammatory cytokines during external beam radiation therapy for prostate cancer: A prospective study

Emma B. Holliday, Nathan F. Dieckmann, Tasha L. McDonald, Arthur Y. Hung, Charles R. Thomas, Lisa J. Wood

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Background and purpose Mechanisms of fatigue reported during radiotherapy are poorly defined but may include inflammatory cytokines and/or sleep disturbances. This prospective, longitudinal, phase II study assessed fatigue, sleep, and serum cytokine levels during radiotherapy for early-stage prostate cancer (PCa). Material and methods Twenty-eight men undergoing radiotherapy for early-stage PCa wore an Actiwatch Score to record fatigue level, sleep time, onset latency, efficiency and wake after sleep onset. Serum levels of IL-1α, IL-1β, TNF-α, IL-6, IL-8, IL-10 and VEGF were measured weekly during radiotherapy. Patient reported quality of life (QOL) metrics were collected before and after treatment. Linear mixed effects models examined trajectories across treatment weeks. Results Fatigue increased across treatment weeks (P <.01), and fatigue was associated with decreased patient-reported QOL. Sleep efficiency increased across treatment weeks (rate of change over time =.29, P =.03), and sleep onset latency decreased (rate of change over time =.86, P =.06). IL-6 tended to increase during treatment (P = 0.09), but none of the cytokine levels or sleep variables were significantly related to fatigue trajectories. Conclusions Despite increased sleep efficiency across treatment weeks, fatigue significantly increased. Although IL-6 increased during the course of radiotherapy, cytokines levels were not associated with fatigue scores or sleep disturbance. Further studies are needed to define the mechanisms for fatigue during radiotherapy.

Original languageEnglish (US)
Pages (from-to)105-111
Number of pages7
JournalRadiotherapy and Oncology
Volume118
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • Cancer treatment related fatigue
  • Cytokines
  • Prosate Cancer
  • Radiotherapy
  • Sleep disturbance

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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