Relationship between clinical measures and histopathologic findings in chronic rhinosinusitis

Zachary M. Soler, David Sauer, Jess Mace, Timothy Smith

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Objective: Describe detailed histopathologic findings from a cohort of patients with chronic rhinosinusitis and evaluate whether histologic measures correlate with baseline clinical factors. Study Design: Cross-sectional study with planned data collection. Setting: Tertiary medical center. Subjects and Methods: Adult patients with chronic rhinosinusitis were prospectively enrolled and demographic data and medical comorbidities recorded. Disease severity was measured by computed tomography (CT), endoscopy, Smell Identification Test (SIT), the Chronic Sinusitis Survey, Rhinosinusitis Disability Index, and SF-36 General Health Survey. Mucosal specimens were assessed for the presence of mucosal inflammation, including cellular (eosinophils, neutrophils, lymphocytes, mast cells, plasma cells, macrophages), epithelial (squamous metaplasia, basement membrane thickening, goblet cells), and stromal markers (subepithelial edema, fibrosis). Histopathologic findings were correlated to baseline clinical factors. Results: A total of 147 subjects were enrolled with histologic samples available for review. Presence of inflammatory markers was diverse, with lymphocytes present in 100 percent of subjects, eosinophils in 49.7 percent, and neutrophils found in 0.7 percent. Total eosinophil counts correlated with the presence of nasal polyposis (r = -0.367; P <0.001), asthma (r = 0.264; P = 0.001), and aspirin intolerance (r = 0.279; P = 0.001). Mucosal eosinophilia correlated with worse disease severity on CT (r = 0.414; P <0.001), endoscopy (r = 0.376; P <0.001), and SIT (r = -0.253; P = 0.002), with the highest correlations seen in subgroups without nasal polyps. Histopathologic findings did not significantly correlate with any quality-of-life measure. Conclusion: Mucosal eosinophilia correlates with objective disease severity as defined by CT, endoscopy, and SIT scores. Although other histologic markers of inflammation are present, none show similar correlations. The presence of mucosal eosinophils does not correlate with quality-of-life scores.

Original languageEnglish (US)
Pages (from-to)454-461
Number of pages8
JournalOtolaryngology - Head and Neck Surgery
Volume141
Issue number4
DOIs
StatePublished - Oct 2009

Fingerprint

Eosinophils
Smell
Endoscopy
Tomography
Eosinophilia
Neutrophils
Quality of Life
Lymphocytes
Inflammation
Nasal Polyps
Goblet Cells
Sinusitis
Metaplasia
Plasma Cells
Health Surveys
Nose
Basement Membrane
Mast Cells
Aspirin
Comorbidity

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Cite this

Relationship between clinical measures and histopathologic findings in chronic rhinosinusitis. / Soler, Zachary M.; Sauer, David; Mace, Jess; Smith, Timothy.

In: Otolaryngology - Head and Neck Surgery, Vol. 141, No. 4, 10.2009, p. 454-461.

Research output: Contribution to journalArticle

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