Relations between respiratory symptoms and spirometric values in young adults: The European community respiratory health study

Jordi Sunyer; Xavier Basagaña; Josep Roca; Isabel Urrutia; Angels Jaen; Josep M. Antó; Peter Burney; S. Chinn; C. Luczynska; D. Jarvis; E. Lai; M. Abramson; J. Kutin; P. Vermeire; F. van Bastelaer; J. Bousquet; F. Neukirch; R. Liard; I. Pin; C. Pison; A. Taytard; H. Magnussen; D. Nowak; H. E. Wichmann; J. Heinrich; T. Gislason; D. Gislason; J. Prichard; S. Allwright; D. Macleod; M. Bugiani; C. Bucca; C. Romano; R. de Marco; V. Lo Cascio; C. Campello; A. Marinoni; I. Cerveri; L. Casali; B. Rijcken; A. Kremer; J. Crane; S. Lewis; A. Gulsvik; E. Omenaas; M. Kogevinas; N. Muniozguren; A. Capelastegui; J. Martinez-Moratalla; E. Almar; J. Maldonado; A. Pereira; J. Sánchez; F. Payo; I. Huerta; G. Boman; C. Janson; E. Bjornsson; L. Rosenhall; E. Norrman; B. Lundback; N. Lindholm; P. Plasche; U. Ackermann-Liebrich; N. Künzli; A. Perruchoud; M. Burr; J. Layzqll; R. Hall; B. Harrison; J. Stark; S. Buist; W. Vollmer; Molly Osborne

doi:10.1016/j.rmed.2004.01.013

Relations between respiratory symptoms and spirometric values in young adults: The European community respiratory health study

Jordi Sunyer, Xavier Basagaña, Josep Roca, Isabel Urrutia, Angels Jaen, Josep M. Antó, Peter Burney, S. Chinn, C. Luczynska, D. Jarvis, E. Lai, M. Abramson, J. Kutin, P. Vermeire, F. van Bastelaer, J. Bousquet, F. Neukirch, R. Liard, I. Pin, C. PisonA. Taytard, H. Magnussen, D. Nowak, H. E. Wichmann, J. Heinrich, T. Gislason, D. Gislason, J. Prichard, S. Allwright, D. Macleod, M. Bugiani, C. Bucca, C. Romano, R. de Marco, V. Lo Cascio, C. Campello, A. Marinoni, I. Cerveri, L. Casali, B. Rijcken, A. Kremer, J. Crane, S. Lewis, A. Gulsvik, E. Omenaas, M. Kogevinas, N. Muniozguren, A. Capelastegui, J. Martinez-Moratalla, E. Almar, J. Maldonado, A. Pereira, J. Sánchez, F. Payo, I. Huerta, G. Boman, C. Janson, E. Bjornsson, L. Rosenhall, E. Norrman, B. Lundback, N. Lindholm, P. Plasche, U. Ackermann-Liebrich, N. Künzli, A. Perruchoud, M. Burr, J. Layzqll, R. Hall, B. Harrison, J. Stark, S. Buist, W. Vollmer, Molly Osborne

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

We aim to assess whether respiratory symptoms are associated with lung function in young adults, and whether any such relation is similar in those with asthma, in men and women, and in different countries. Study participants (aged 20-44 years) were randomly selected from the general population in 35 centres in 15 countries as part of the European Community Respiratory Health Study. In all, 12,541 subjects (47%) completed a respiratory symptoms questionnaire and spirometry, metacholine challenge and immunoglobulin E tests. Indicators of diagnosed asthma showed the largest association with airways obstruction (FEV₁-maximal 1-s forced expiratory volume/forced vital capacity-FVC<70%), followed by symptoms of wheezing or shortness of breath, in both genders. Among the 96% of subjects whose FEV₁/FVC ratios were greater or equal to 70%, wheezing or shortness of breath was associated with lower FEV₁levels (-211 ml in men and -169 ml in women (P<0.01)), independent of diagnosed asthma, smoking, atopy or bronchial responsiveness. This association was not explained by a lower FVC. Symptoms of chronic bronchial mucus hypersecretion (chronic phlegm) were unrelated to both airways obstruction and FEV₁levels. Findings were homogeneous across all centres. These results suggest that lung diseases that cause wheezing are generally associated with impaired lung function.

Original language	English (US)
Pages (from-to)	1025-1033
Number of pages	9
Journal	Respiratory Medicine
Volume	98
Issue number	10
DOIs	https://doi.org/10.1016/j.rmed.2004.01.013
State	Published - 2004

Keywords

Asthma
Bronchial obstruction
FEV
FVC
Factor analysis
Lung function
Respiratory symptoms
Wheezing

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Access to Document

10.1016/j.rmed.2004.01.013

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Sunyer, J., Basagaña, X., Roca, J., Urrutia, I., Jaen, A., Antó, J. M., Burney, P., Chinn, S., Luczynska, C., Jarvis, D., Lai, E., Abramson, M., Kutin, J., Vermeire, P., van Bastelaer, F., Bousquet, J., Neukirch, F., Liard, R., Pin, I., ... Osborne, M. (2004). Relations between respiratory symptoms and spirometric values in young adults: The European community respiratory health study. Respiratory Medicine, 98(10), 1025-1033. https://doi.org/10.1016/j.rmed.2004.01.013

Sunyer, J, Basagaña, X, Roca, J, Urrutia, I, Jaen, A, Antó, JM, Burney, P, Chinn, S, Luczynska, C, Jarvis, D, Lai, E, Abramson, M, Kutin, J, Vermeire, P, van Bastelaer, F, Bousquet, J, Neukirch, F, Liard, R, Pin, I, Pison, C, Taytard, A, Magnussen, H, Nowak, D, Wichmann, HE, Heinrich, J, Gislason, T, Gislason, D, Prichard, J, Allwright, S, Macleod, D, Bugiani, M, Bucca, C, Romano, C, de Marco, R, Lo Cascio, V, Campello, C, Marinoni, A, Cerveri, I, Casali, L, Rijcken, B, Kremer, A, Crane, J, Lewis, S, Gulsvik, A, Omenaas, E, Kogevinas, M, Muniozguren, N, Capelastegui, A, Martinez-Moratalla, J, Almar, E, Maldonado, J, Pereira, A, Sánchez, J, Payo, F, Huerta, I, Boman, G, Janson, C, Bjornsson, E, Rosenhall, L, Norrman, E, Lundback, B, Lindholm, N, Plasche, P, Ackermann-Liebrich, U, Künzli, N, Perruchoud, A, Burr, M, Layzqll, J, Hall, R, Harrison, B, Stark, J, Buist, S, Vollmer, W & Osborne, M 2004, 'Relations between respiratory symptoms and spirometric values in young adults: The European community respiratory health study', Respiratory Medicine, vol. 98, no. 10, pp. 1025-1033. https://doi.org/10.1016/j.rmed.2004.01.013

@article{39c8e1ae7e6c4b0882c13173665f0260,

title = "Relations between respiratory symptoms and spirometric values in young adults: The European community respiratory health study",

abstract = "We aim to assess whether respiratory symptoms are associated with lung function in young adults, and whether any such relation is similar in those with asthma, in men and women, and in different countries. Study participants (aged 20-44 years) were randomly selected from the general population in 35 centres in 15 countries as part of the European Community Respiratory Health Study. In all, 12,541 subjects (47%) completed a respiratory symptoms questionnaire and spirometry, metacholine challenge and immunoglobulin E tests. Indicators of diagnosed asthma showed the largest association with airways obstruction (FEV1-maximal 1-s forced expiratory volume/forced vital capacity-FVC<70%), followed by symptoms of wheezing or shortness of breath, in both genders. Among the 96% of subjects whose FEV1/FVC ratios were greater or equal to 70%, wheezing or shortness of breath was associated with lower FEV1levels (-211 ml in men and -169 ml in women (P<0.01)), independent of diagnosed asthma, smoking, atopy or bronchial responsiveness. This association was not explained by a lower FVC. Symptoms of chronic bronchial mucus hypersecretion (chronic phlegm) were unrelated to both airways obstruction and FEV1levels. Findings were homogeneous across all centres. These results suggest that lung diseases that cause wheezing are generally associated with impaired lung function.",

keywords = "Asthma, Bronchial obstruction, FEV, FVC, Factor analysis, Lung function, Respiratory symptoms, Wheezing",

author = "Jordi Sunyer and Xavier Basaga{\~n}a and Josep Roca and Isabel Urrutia and Angels Jaen and Ant{\'o}, {Josep M.} and Peter Burney and S. Chinn and C. Luczynska and D. Jarvis and E. Lai and M. Abramson and J. Kutin and P. Vermeire and {van Bastelaer}, F. and J. Bousquet and F. Neukirch and R. Liard and I. Pin and C. Pison and A. Taytard and H. Magnussen and D. Nowak and Wichmann, {H. E.} and J. Heinrich and T. Gislason and D. Gislason and J. Prichard and S. Allwright and D. Macleod and M. Bugiani and C. Bucca and C. Romano and {de Marco}, R. and {Lo Cascio}, V. and C. Campello and A. Marinoni and I. Cerveri and L. Casali and B. Rijcken and A. Kremer and J. Crane and S. Lewis and A. Gulsvik and E. Omenaas and M. Kogevinas and N. Muniozguren and A. Capelastegui and J. Martinez-Moratalla and E. Almar and J. Maldonado and A. Pereira and J. S{\'a}nchez and F. Payo and I. Huerta and G. Boman and C. Janson and E. Bjornsson and L. Rosenhall and E. Norrman and B. Lundback and N. Lindholm and P. Plasche and U. Ackermann-Liebrich and N. K{\"u}nzli and A. Perruchoud and M. Burr and J. Layzqll and R. Hall and B. Harrison and J. Stark and S. Buist and W. Vollmer and Molly Osborne",

note = "Funding Information: The co-ordination of this work was supported by the European Commission and we are grateful to Colette Baya and Dr. Manuel Hallen for their help during the study and to Professor K Vuylsteek and the members of the COMAC for their support. The following grants helped to fund the local studies: Australia: Allen and Hanbury's, Australia. Belgium: Belgian Science Policy Office, National Fund for Scientific Research. France: Ministere de la Sant{\'e}, Glaxo France, Insitut Pneumologique d{\textquoteright}Aquitaine, Contrat de Plan Etat-R{\'e}gion Languedoc-Rousillon, CNMATS, CNMRT (90MR/10, 91AF/6), Ministre delegu{\'e} de la sant{\'e}, RNSP. Germany: GSF, and the Bundesminister f{\"u}r Forschung und Technologie, Bonn. Ita1y: Ministero dell{\textquoteright}Universita e della Ricerca Scientifica e Tecnologica, CNR, Regione Veneto grant RSF no. 381/05.93. New Zealand: Asthma Foundation of New Zealand, Lotteries Grant Board, Health Research Council of New Zealand. Norway: Norwegian Research Council project no. 101422/310. Spain: Ministero Sanidad y Consumo FIS grants #91/0016060/00E-05E., #92/0319, #93/0393, Hospital General de Albacete, Hospital General Juan Ram{\'o}n Jim{\'e}nez, Consejeria de Sanidad Principado de Asturias. Sweden: The Swedish Medical Research Council, the Swedish Heart Lung Foundation, the Swedish Association against Asthma and Allergy. Switzerland: Swiss National Science Foundation grant 4026-28099. United Kingdom: National Asthma Campaign, British Lung Foundation, Department of Health, South Thames Regional Health Authority. USA: United States Department of Health, Education and Welfare Public Health Service Grant #2 S07 RR05521-28.",

year = "2004",

doi = "10.1016/j.rmed.2004.01.013",

language = "English (US)",

volume = "98",

pages = "1025--1033",

journal = "Respiratory Medicine",

issn = "0954-6111",

publisher = "W.B. Saunders Ltd",

number = "10",

}

TY - JOUR

T1 - Relations between respiratory symptoms and spirometric values in young adults

T2 - The European community respiratory health study

AU - Sunyer, Jordi

AU - Basagaña, Xavier

AU - Roca, Josep

AU - Urrutia, Isabel

AU - Jaen, Angels

AU - Antó, Josep M.

AU - Burney, Peter

AU - Chinn, S.

AU - Luczynska, C.

AU - Jarvis, D.

AU - Lai, E.

AU - Abramson, M.

AU - Kutin, J.

AU - Vermeire, P.

AU - van Bastelaer, F.

AU - Bousquet, J.

AU - Neukirch, F.

AU - Liard, R.

AU - Pin, I.

AU - Pison, C.

AU - Taytard, A.

AU - Magnussen, H.

AU - Nowak, D.

AU - Wichmann, H. E.

AU - Heinrich, J.

AU - Gislason, T.

AU - Gislason, D.

AU - Prichard, J.

AU - Allwright, S.

AU - Macleod, D.

AU - Bugiani, M.

AU - Bucca, C.

AU - Romano, C.

AU - de Marco, R.

AU - Lo Cascio, V.

AU - Campello, C.

AU - Marinoni, A.

AU - Cerveri, I.

AU - Casali, L.

AU - Rijcken, B.

AU - Kremer, A.

AU - Crane, J.

AU - Lewis, S.

AU - Gulsvik, A.

AU - Omenaas, E.

AU - Kogevinas, M.

AU - Muniozguren, N.

AU - Capelastegui, A.

AU - Martinez-Moratalla, J.

AU - Almar, E.

AU - Maldonado, J.

AU - Pereira, A.

AU - Sánchez, J.

AU - Payo, F.

AU - Huerta, I.

AU - Boman, G.

AU - Janson, C.

AU - Bjornsson, E.

AU - Rosenhall, L.

AU - Norrman, E.

AU - Lundback, B.

AU - Lindholm, N.

AU - Plasche, P.

AU - Ackermann-Liebrich, U.

AU - Künzli, N.

AU - Perruchoud, A.

AU - Burr, M.

AU - Layzqll, J.

AU - Hall, R.

AU - Harrison, B.

AU - Stark, J.

AU - Buist, S.

AU - Vollmer, W.

AU - Osborne, Molly

N1 - Funding Information: The co-ordination of this work was supported by the European Commission and we are grateful to Colette Baya and Dr. Manuel Hallen for their help during the study and to Professor K Vuylsteek and the members of the COMAC for their support. The following grants helped to fund the local studies: Australia: Allen and Hanbury's, Australia. Belgium: Belgian Science Policy Office, National Fund for Scientific Research. France: Ministere de la Santé, Glaxo France, Insitut Pneumologique d’Aquitaine, Contrat de Plan Etat-Région Languedoc-Rousillon, CNMATS, CNMRT (90MR/10, 91AF/6), Ministre delegué de la santé, RNSP. Germany: GSF, and the Bundesminister für Forschung und Technologie, Bonn. Ita1y: Ministero dell’Universita e della Ricerca Scientifica e Tecnologica, CNR, Regione Veneto grant RSF no. 381/05.93. New Zealand: Asthma Foundation of New Zealand, Lotteries Grant Board, Health Research Council of New Zealand. Norway: Norwegian Research Council project no. 101422/310. Spain: Ministero Sanidad y Consumo FIS grants #91/0016060/00E-05E., #92/0319, #93/0393, Hospital General de Albacete, Hospital General Juan Ramón Jiménez, Consejeria de Sanidad Principado de Asturias. Sweden: The Swedish Medical Research Council, the Swedish Heart Lung Foundation, the Swedish Association against Asthma and Allergy. Switzerland: Swiss National Science Foundation grant 4026-28099. United Kingdom: National Asthma Campaign, British Lung Foundation, Department of Health, South Thames Regional Health Authority. USA: United States Department of Health, Education and Welfare Public Health Service Grant #2 S07 RR05521-28.

PY - 2004

Y1 - 2004

N2 - We aim to assess whether respiratory symptoms are associated with lung function in young adults, and whether any such relation is similar in those with asthma, in men and women, and in different countries. Study participants (aged 20-44 years) were randomly selected from the general population in 35 centres in 15 countries as part of the European Community Respiratory Health Study. In all, 12,541 subjects (47%) completed a respiratory symptoms questionnaire and spirometry, metacholine challenge and immunoglobulin E tests. Indicators of diagnosed asthma showed the largest association with airways obstruction (FEV1-maximal 1-s forced expiratory volume/forced vital capacity-FVC<70%), followed by symptoms of wheezing or shortness of breath, in both genders. Among the 96% of subjects whose FEV1/FVC ratios were greater or equal to 70%, wheezing or shortness of breath was associated with lower FEV1levels (-211 ml in men and -169 ml in women (P<0.01)), independent of diagnosed asthma, smoking, atopy or bronchial responsiveness. This association was not explained by a lower FVC. Symptoms of chronic bronchial mucus hypersecretion (chronic phlegm) were unrelated to both airways obstruction and FEV1levels. Findings were homogeneous across all centres. These results suggest that lung diseases that cause wheezing are generally associated with impaired lung function.

AB - We aim to assess whether respiratory symptoms are associated with lung function in young adults, and whether any such relation is similar in those with asthma, in men and women, and in different countries. Study participants (aged 20-44 years) were randomly selected from the general population in 35 centres in 15 countries as part of the European Community Respiratory Health Study. In all, 12,541 subjects (47%) completed a respiratory symptoms questionnaire and spirometry, metacholine challenge and immunoglobulin E tests. Indicators of diagnosed asthma showed the largest association with airways obstruction (FEV1-maximal 1-s forced expiratory volume/forced vital capacity-FVC<70%), followed by symptoms of wheezing or shortness of breath, in both genders. Among the 96% of subjects whose FEV1/FVC ratios were greater or equal to 70%, wheezing or shortness of breath was associated with lower FEV1levels (-211 ml in men and -169 ml in women (P<0.01)), independent of diagnosed asthma, smoking, atopy or bronchial responsiveness. This association was not explained by a lower FVC. Symptoms of chronic bronchial mucus hypersecretion (chronic phlegm) were unrelated to both airways obstruction and FEV1levels. Findings were homogeneous across all centres. These results suggest that lung diseases that cause wheezing are generally associated with impaired lung function.

KW - Asthma

KW - Bronchial obstruction

KW - FEV

KW - FVC

KW - Factor analysis

KW - Lung function

KW - Respiratory symptoms

KW - Wheezing

UR - http://www.scopus.com/inward/record.url?scp=19944388884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19944388884&partnerID=8YFLogxK

U2 - 10.1016/j.rmed.2004.01.013

DO - 10.1016/j.rmed.2004.01.013

M3 - Article

C2 - 15481280

AN - SCOPUS:19944388884

SN - 0954-6111

VL - 98

SP - 1025

EP - 1033

JO - Respiratory Medicine

JF - Respiratory Medicine

IS - 10

ER -

Relations between respiratory symptoms and spirometric values in young adults: The European community respiratory health study

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