Relation of whole blood n-3 fatty acid levels to exercise parameters in patients with stable coronary artery disease (from the heart and soul study)

Brian Moyers, Ramin Farzaneh-Far, William Harris, Sachin Garg, Beeya Na, Mary A. Whooley

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Dietary intake of n-3 polyunsaturated fatty acids is associated with a lower incidence of cardiovascular events. Mechanisms underlying this association are poorly understood but may include beneficial effects on physical conditioning and vagal tone. We investigated the association of n-3 fatty acid levels to exercise parameters in 992 subjects with stable coronary artery disease. Cross-sectional associations of heart rate recovery time, treadmill exercise capacity, and exercise time with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) levels were evaluated in multivariable linear and logistic regression models adjusted for demographics, cardiovascular risk factors, co-morbidities, self-reported physical activity, medication use, and left ventricular function. After multivariable adjustment, n-3 fatty acid levels (DHA + EPA) were strongly associated with heart rate recovery (beta 2.1, p = 0.003), exercise capacity (beta 0.8, p 0.1 for all comparisons). In conclusion, an independent association exists between n-3 fatty acid levels and important exercise parameters in patients with stable coronary artery disease. These findings support the hypothesis that n-3 fatty acids may increase vagal tone and physical conditioning.

Original languageEnglish (US)
Pages (from-to)1149-1154
Number of pages6
JournalAmerican Journal of Cardiology
Volume107
Issue number8
DOIs
StatePublished - Apr 15 2011
Externally publishedYes

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Omega-3 Fatty Acids
Coronary Artery Disease
Exercise
Eicosapentaenoic Acid
Docosahexaenoic Acids
Heart Rate
Logistic Models
Left Ventricular Function
Linear Models
Demography
Morbidity
Incidence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Relation of whole blood n-3 fatty acid levels to exercise parameters in patients with stable coronary artery disease (from the heart and soul study). / Moyers, Brian; Farzaneh-Far, Ramin; Harris, William; Garg, Sachin; Na, Beeya; Whooley, Mary A.

In: American Journal of Cardiology, Vol. 107, No. 8, 15.04.2011, p. 1149-1154.

Research output: Contribution to journalArticle

Moyers, Brian ; Farzaneh-Far, Ramin ; Harris, William ; Garg, Sachin ; Na, Beeya ; Whooley, Mary A. / Relation of whole blood n-3 fatty acid levels to exercise parameters in patients with stable coronary artery disease (from the heart and soul study). In: American Journal of Cardiology. 2011 ; Vol. 107, No. 8. pp. 1149-1154.
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