Relation of visceral adiposity to circulating natriuretic peptides in ambulatory individuals

Susan Cheng, Caroline S. Fox, Martin G. Larson, Joseph M. Massaro, Elizabeth L. McCabe, Abigail Khan, Daniel Levy, Udo Hoffmann, Christopher J. O'Donnell, Karen K. Miller, Christopher Newton-Cheh, Andrea D. Coviello, Shalender Bhasin, Ramachandran S. Vasan, Thomas J. Wang

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Natriuretic peptides have important roles in the regulation of vasomotor tone, salt homeostasis, and ventricular remodeling. Lower natriuretic peptide levels observed in obese individuals may underlie the greater cardiovascular risk associated with obesity. Thus the aim of this study was to determine whether lower natriuretic peptide levels in obesity are attributable to differences in regional fat distribution. We investigated the relation of plasma N-terminal proB-type natriuretic peptide (NTpro-BNP) to regional adiposity in 1,873 community-based individuals (46% women, mean age 45 years). Subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) volumes were measured by multidetector computed tomography. In gender-specific multivariable analyses adjusting for age and blood pressure, log NTpro-BNP was inversely associated with VAT in men (beta -0.11 per standard deviation increment, p

Original languageEnglish (US)
Pages (from-to)979-984
Number of pages6
JournalAmerican Journal of Cardiology
Volume108
Issue number7
DOIs
StatePublished - Oct 1 2011
Externally publishedYes

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Natriuretic Peptides
Adiposity
Intra-Abdominal Fat
Obesity
Ventricular Remodeling
Multidetector Computed Tomography
Subcutaneous Fat
Homeostasis
Salts
Fats
Blood Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Relation of visceral adiposity to circulating natriuretic peptides in ambulatory individuals. / Cheng, Susan; Fox, Caroline S.; Larson, Martin G.; Massaro, Joseph M.; McCabe, Elizabeth L.; Khan, Abigail; Levy, Daniel; Hoffmann, Udo; O'Donnell, Christopher J.; Miller, Karen K.; Newton-Cheh, Christopher; Coviello, Andrea D.; Bhasin, Shalender; Vasan, Ramachandran S.; Wang, Thomas J.

In: American Journal of Cardiology, Vol. 108, No. 7, 01.10.2011, p. 979-984.

Research output: Contribution to journalArticle

Cheng, S, Fox, CS, Larson, MG, Massaro, JM, McCabe, EL, Khan, A, Levy, D, Hoffmann, U, O'Donnell, CJ, Miller, KK, Newton-Cheh, C, Coviello, AD, Bhasin, S, Vasan, RS & Wang, TJ 2011, 'Relation of visceral adiposity to circulating natriuretic peptides in ambulatory individuals', American Journal of Cardiology, vol. 108, no. 7, pp. 979-984. https://doi.org/10.1016/j.amjcard.2011.05.033
Cheng, Susan ; Fox, Caroline S. ; Larson, Martin G. ; Massaro, Joseph M. ; McCabe, Elizabeth L. ; Khan, Abigail ; Levy, Daniel ; Hoffmann, Udo ; O'Donnell, Christopher J. ; Miller, Karen K. ; Newton-Cheh, Christopher ; Coviello, Andrea D. ; Bhasin, Shalender ; Vasan, Ramachandran S. ; Wang, Thomas J. / Relation of visceral adiposity to circulating natriuretic peptides in ambulatory individuals. In: American Journal of Cardiology. 2011 ; Vol. 108, No. 7. pp. 979-984.
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