Relation of lactate production to postischaemic reduction in function and myocardial oxygen consumption after partial coronary occlusion in swine

Edward O. Mcfalls, George Pantely, Ton O. Ophuis, Cheryl G. Anselone, J. David Bristow

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Summary: Postischaemic myocardial dysfunction (stunning) induced by partial occlusion of the left anterior descending coronary artery and its relation to lactate production during reperfusion were studied in nine swine. A 40% reduction in regional left ventricular wall thickening, as measured by ultrasonic crystals, was prospectively defined as stunning. A perfusion pressure of 20 mmHg was maintained with a hydraulic occluder for each ischaemic period and was monitored by a distal arterial catheter. To achieve a 40% reduction in function, four animals required three ischaemic periods (mean ischaemic flow reduction 73%), four two (86% flow reduction), and one one (93% flow reduction). At 25 min of reperfusion transmural flow was slightly reduced from 0.67 ml·g-1 ·min-1 at control to 0.58 ml·g-1·min-1 (p-1 to 2.7 ml·min-1 occurred (p

    Original languageEnglish (US)
    Pages (from-to)856-862
    Number of pages7
    JournalCardiovascular Research
    Volume21
    Issue number11
    DOIs
    StatePublished - Nov 1987

    Keywords

    • Anaerobic glycolysis
    • Ischaemia
    • Myocardial metabolism
    • Postischaemic dysfunction
    • Reperfusion
    • Stunned myocardium

    ASJC Scopus subject areas

    • Statistics, Probability and Uncertainty
    • Applied Mathematics
    • Physiology (medical)
    • Physiology
    • Cardiology and Cardiovascular Medicine

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