Abstract
In the setting of chronic coronary stenoses, percent wall thickening (%WT) both at rest and during catecholamine stimulation can be abnormal despite normal resting myocardial blood flow (MBF). We hypothesized that this phenomenon is related to abnormal MBF reserve. Accordingly, 15 dogs were studied between 7 and 10 days after placement of Ameroid constrictors around the proximal coronary arteries and their major branches, at a time when collateral development had not yet occurred. %WT and MBF were measured at rest, after 0.56 mg/kg of dipyridamole, and at incremental doses of dobutamine (5-40 μg·kg-1·min-1). Resting %WT and MBF were normal in all four sham dogs. Resting transmural MBF was normal in all segments in the 11 study dogs, despite reduced (-2 SD of normal) %WT (-1·min-1, above which those with abnormal endocardial MBF reserve showed a 'biphasic' response. It is concluded that, in the presence of chronic coronary stenoses, abnormalities in resting %WT as well as inducible reduction in %WT during pharmacological stress are related to the degree of abnormal MBF reserve.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Physiology - Heart and Circulatory Physiology |
| Volume | 279 |
| Issue number | 6 48-6 |
| State | Published - 2000 |
| Externally published | Yes |
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Keywords
- Dobutamine echocardiography
- Resting regional dysfunction
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Relation between regional function and coronary blood flow reserve in multivessel coronary artery stenosis. / Bin, Jian Ping; Pelberg, Robert A.; Wei, Kevin; Coggins, Matthew; Goodman, N. Craig; Kaul, Sanjiv.
In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 279, No. 6 48-6, 2000.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relation between regional function and coronary blood flow reserve in multivessel coronary artery stenosis
AU - Bin, Jian Ping
AU - Pelberg, Robert A.
AU - Wei, Kevin
AU - Coggins, Matthew
AU - Goodman, N. Craig
AU - Kaul, Sanjiv
PY - 2000
Y1 - 2000
N2 - In the setting of chronic coronary stenoses, percent wall thickening (%WT) both at rest and during catecholamine stimulation can be abnormal despite normal resting myocardial blood flow (MBF). We hypothesized that this phenomenon is related to abnormal MBF reserve. Accordingly, 15 dogs were studied between 7 and 10 days after placement of Ameroid constrictors around the proximal coronary arteries and their major branches, at a time when collateral development had not yet occurred. %WT and MBF were measured at rest, after 0.56 mg/kg of dipyridamole, and at incremental doses of dobutamine (5-40 μg·kg-1·min-1). Resting %WT and MBF were normal in all four sham dogs. Resting transmural MBF was normal in all segments in the 11 study dogs, despite reduced (-2 SD of normal) %WT (-1·min-1, above which those with abnormal endocardial MBF reserve showed a 'biphasic' response. It is concluded that, in the presence of chronic coronary stenoses, abnormalities in resting %WT as well as inducible reduction in %WT during pharmacological stress are related to the degree of abnormal MBF reserve.
AB - In the setting of chronic coronary stenoses, percent wall thickening (%WT) both at rest and during catecholamine stimulation can be abnormal despite normal resting myocardial blood flow (MBF). We hypothesized that this phenomenon is related to abnormal MBF reserve. Accordingly, 15 dogs were studied between 7 and 10 days after placement of Ameroid constrictors around the proximal coronary arteries and their major branches, at a time when collateral development had not yet occurred. %WT and MBF were measured at rest, after 0.56 mg/kg of dipyridamole, and at incremental doses of dobutamine (5-40 μg·kg-1·min-1). Resting %WT and MBF were normal in all four sham dogs. Resting transmural MBF was normal in all segments in the 11 study dogs, despite reduced (-2 SD of normal) %WT (-1·min-1, above which those with abnormal endocardial MBF reserve showed a 'biphasic' response. It is concluded that, in the presence of chronic coronary stenoses, abnormalities in resting %WT as well as inducible reduction in %WT during pharmacological stress are related to the degree of abnormal MBF reserve.
KW - Dobutamine echocardiography
KW - Resting regional dysfunction
UR - http://www.scopus.com/inward/record.url?scp=0034536391&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034536391&partnerID=8YFLogxK
M3 - Article
C2 - 11087264
AN - SCOPUS:0034536391
VL - 279
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
SN - 1931-857X
IS - 6 48-6
ER -