Relation between fibroblast growth factor-23, body weight and bone mineral density in elderly men

R. Marsell, M. A I Mirza, H. Mallmin, M. Karlsson, D. Mellström, Eric Orwoll, C. Ohlsson, K. B. Jonsson, Ö Ljunggren, T. E. Larsson

Research output: Contribution to journalArticle

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Abstract

We evaluated the relation between serum FGF23 and bone mineral density (BMD) in a community-based cohort of elderly men. There was a weak correlation between FGF23 and BMD, which was primarily dependent on body weight. Introduction: FGF23 is a hormonal factor produced in bone and regulates serum levels of phosphate (Pi) and vitamin D. FGF23 over-expression is associated with skeletal abnormalities, including rickets/osteomalacia. The relation between FGF23 and Bone Mineral Density (BMD) in the community remains unexplored. Methods: We employed a large, population-based cohort of 3014 Swedish men aged 69-80 years, without known renal disease. BMD was measured with dual X-ray absorptiometry (DXA) in the hip and lumbar spine. Serum intact FGF23 was analyzed with a two-site monoclonal ELISA. Results: There was a weak but significant correlation between FGF23 and BMD in femoral neck (r=0.04, p

Original languageEnglish (US)
Pages (from-to)1167-1173
Number of pages7
JournalOsteoporosis International
Volume20
Issue number7
DOIs
StatePublished - Jul 2009

Fingerprint

Bone Density
Body Weight
Serum
Osteomalacia
Rickets
Femur Neck
Photon Absorptiometry
Vitamin D
Hip
Spine
Enzyme-Linked Immunosorbent Assay
Phosphates
fibroblast growth factor 23
Kidney
Bone and Bones
Population

Keywords

  • BMD
  • Bone densitometry
  • Bone mineralization
  • FGF-23
  • Fibroblast growth factor 23
  • Growth factors

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Marsell, R., Mirza, M. A. I., Mallmin, H., Karlsson, M., Mellström, D., Orwoll, E., ... Larsson, T. E. (2009). Relation between fibroblast growth factor-23, body weight and bone mineral density in elderly men. Osteoporosis International, 20(7), 1167-1173. https://doi.org/10.1007/s00198-008-0780-2

Relation between fibroblast growth factor-23, body weight and bone mineral density in elderly men. / Marsell, R.; Mirza, M. A I; Mallmin, H.; Karlsson, M.; Mellström, D.; Orwoll, Eric; Ohlsson, C.; Jonsson, K. B.; Ljunggren, Ö; Larsson, T. E.

In: Osteoporosis International, Vol. 20, No. 7, 07.2009, p. 1167-1173.

Research output: Contribution to journalArticle

Marsell, R, Mirza, MAI, Mallmin, H, Karlsson, M, Mellström, D, Orwoll, E, Ohlsson, C, Jonsson, KB, Ljunggren, Ö & Larsson, TE 2009, 'Relation between fibroblast growth factor-23, body weight and bone mineral density in elderly men', Osteoporosis International, vol. 20, no. 7, pp. 1167-1173. https://doi.org/10.1007/s00198-008-0780-2
Marsell, R. ; Mirza, M. A I ; Mallmin, H. ; Karlsson, M. ; Mellström, D. ; Orwoll, Eric ; Ohlsson, C. ; Jonsson, K. B. ; Ljunggren, Ö ; Larsson, T. E. / Relation between fibroblast growth factor-23, body weight and bone mineral density in elderly men. In: Osteoporosis International. 2009 ; Vol. 20, No. 7. pp. 1167-1173.
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