Relation between amygdala structure and function in adolescents with bipolar disorder

Jessica H. Kalmar, Fei Wang, Lara G. Chepenik, Fay Y. Womer, Monique M. Jones, Brian Pittman, Maulik P. Shah, AndréS Martin, R. Todd Constable, Hilary P. Blumberg

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

Objective: Previous study supports the presence of reduced volume and elevated response to emotional stimuli in amygdala in adolescents with bipolar disorder (BD). In the present study, structural and functional magnetic resonance imaging scans were obtained during the same neuroimaging session to examine amygdala structure-function relations in adolescents with BD. We hypothesized that amygdala volume would be inversely associated with amygdala response to emotional stimuli, such that BD participants with the smallest amygdala volumes would exhibit the highest amygdala response. Method: Fifty-one adolescents (21 with BD I and 30 control adolescents, ages 10-18 years) underwent structural and functional magnetic resonance imaging scans. Amygdala volume (n = 49) and signal change (n = 44) during emotional face processing were compared between groups, and structure-function correlations were examined within the BD group (n = 16). Results: Adolescents with BD showed decreased amygdala volume (p = .009) and increased amygdala response to emotional faces (p = .043). There was no significant interaction between diagnosis and emotion type. A significant inverse association between amygdala volume and activation during emotional face processing was observed (r = -0.54, p = .029). Conclusions: Decreased volume and increased response to emotional stimuli in the amygdala in adolescents with BD are consistent with previous reports. This study represents the first report, to our knowledge, of the two findings in the same adolescent BD sample and supports an amygdala structure-function relation characterized by an inverse association between volume and response to emotional stimuli. This preliminary finding requires replication and suggests a possible pathophysiological link between abnormalities in amygdala structure and response to emotional stimuli in BD. J. Am. Acad. Child Adolesc.

Original languageEnglish (US)
Pages (from-to)636-642
Number of pages7
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume48
Issue number6
DOIs
StatePublished - Jun 2009
Externally publishedYes

Keywords

  • Adolescents
  • Amygdala
  • Bipolar disorder
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

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