Relation between air-filled albumin microbubble and red blood cell rheology in the human myocardium

Influence of echocardiographic systems and chest wall attenuation

Suad Ismail, Ananda R. Jayaweera, Gustavo Camarano, Lawrence W. Gimple, Eric R. Powers, Sanjiv Kaul

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Background. We have previously shown that the intravascular rheology of sonicated air-filled albumin microbubbles is similar to that of red blood cells (RBCs) and that their myocardial transit rate is also similar to that of RBCs in the beating canine heart. In the present study, we tested the hypothesis that the myocardial transit rates of these microbubbles reflect those of RBCs in humans at different coronary flow rates. Methods and Results. RBC and microbubble transit rates were measured in 17 patients undergoing coronary angiography: in 8, measurements were made only at rest, whereas in 9, they were performed both at rest and during a pacing-induced increase in coronary blood flow. A γ-variate function was used to derive mean RBC and microbubble transit rates from the time-activity and time- intensity plots after the left main injection of RBCs and microbubbles, respectively. There was linear correlation between the myocardial transit rates with both tracers with the slope of the correlation determined by the specific echocardiographic system that was used. Microbubble transit rate consistently overestimated RBC transit rate due to artificial narrowing of the time-intensity curves caused by chest wall attenuation of the echocardiographic signal, which was confirmed through in vitro experiments. Conclusions. There is close correlation between air-filled albumin microbubbles and RBC rheology in the human myocardium. The use of these microbubbles in the cardiac catheterization laboratory could, therefore, provide further insights into myocardial blood flow/myocardial blood volume relations in humans.

Original languageEnglish (US)
Pages (from-to)445-451
Number of pages7
JournalCirculation
Volume94
Issue number3
StatePublished - 1996
Externally publishedYes

Fingerprint

Microbubbles
Rheology
Thoracic Wall
Albumins
Myocardium
Erythrocytes
Air
Cardiac Catheterization
Blood Volume
Coronary Angiography
Canidae
Injections

Keywords

  • blood flow
  • contrast media
  • echocardiography

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Relation between air-filled albumin microbubble and red blood cell rheology in the human myocardium : Influence of echocardiographic systems and chest wall attenuation. / Ismail, Suad; Jayaweera, Ananda R.; Camarano, Gustavo; Gimple, Lawrence W.; Powers, Eric R.; Kaul, Sanjiv.

In: Circulation, Vol. 94, No. 3, 1996, p. 445-451.

Research output: Contribution to journalArticle

Ismail, Suad ; Jayaweera, Ananda R. ; Camarano, Gustavo ; Gimple, Lawrence W. ; Powers, Eric R. ; Kaul, Sanjiv. / Relation between air-filled albumin microbubble and red blood cell rheology in the human myocardium : Influence of echocardiographic systems and chest wall attenuation. In: Circulation. 1996 ; Vol. 94, No. 3. pp. 445-451.
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