TY - GEN
T1 - Relating optical signals induced by infrared neural stimulation to electrophysiology
AU - Cayce, Jonathan M.
AU - Friedman, Robert
AU - Roe, Anna W.
AU - Konrad, Peter E.
AU - Jansen, E. Duco
AU - Mahadevan-Jansen, Anita
PY - 2010
Y1 - 2010
N2 - Infrared neural stimulation (INS) is well characterized for the peripheral nervous system; however, translation to the central nervous system (CNS) presents a new set of challenges which require us to consider different anatomy, multiple cell types, and the physiology associated with structures in the CNS. This study represents the first attempt to translate INS to in vivo stimulation of the CNS. The results from this study show that INS generates intrinsic optical signals of similar magnitude and shape associated with well characterized mechanical stimuli. Electrophysiology analysis indicates INS evokes inhibitory responses in rat somatosensory cortex. The implications of this work could lead to neural implants which allows for single cell stimulation making it possible to design closed loop neural prosthetics.
AB - Infrared neural stimulation (INS) is well characterized for the peripheral nervous system; however, translation to the central nervous system (CNS) presents a new set of challenges which require us to consider different anatomy, multiple cell types, and the physiology associated with structures in the CNS. This study represents the first attempt to translate INS to in vivo stimulation of the CNS. The results from this study show that INS generates intrinsic optical signals of similar magnitude and shape associated with well characterized mechanical stimuli. Electrophysiology analysis indicates INS evokes inhibitory responses in rat somatosensory cortex. The implications of this work could lead to neural implants which allows for single cell stimulation making it possible to design closed loop neural prosthetics.
UR - http://www.scopus.com/inward/record.url?scp=77955598962&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955598962&partnerID=8YFLogxK
U2 - 10.1109/BSEC.2010.5510836
DO - 10.1109/BSEC.2010.5510836
M3 - Conference contribution
AN - SCOPUS:77955598962
SN - 9781424467143
T3 - Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN
BT - Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010
T2 - 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN
Y2 - 25 May 2010 through 26 May 2010
ER -