Relating optical signals induced by infrared neural stimulation to electrophysiology

Jonathan M. Cayce, Robert Friedman, Anna Roe, Peter E. Konrad, E. Duco Jansen, Anita Mahadevan-Jansen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Infrared neural stimulation (INS) is well characterized for the peripheral nervous system; however, translation to the central nervous system (CNS) presents a new set of challenges which require us to consider different anatomy, multiple cell types, and the physiology associated with structures in the CNS. This study represents the first attempt to translate INS to in vivo stimulation of the CNS. The results from this study show that INS generates intrinsic optical signals of similar magnitude and shape associated with well characterized mechanical stimuli. Electrophysiology analysis indicates INS evokes inhibitory responses in rat somatosensory cortex. The implications of this work could lead to neural implants which allows for single cell stimulation making it possible to design closed loop neural prosthetics.

Original languageEnglish (US)
Title of host publicationProceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN
DOIs
StatePublished - 2010
Externally publishedYes
Event2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN - Oak Ridge, TN, United States
Duration: May 25 2010May 26 2010

Other

Other2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN
CountryUnited States
CityOak Ridge, TN
Period5/25/105/26/10

Fingerprint

Electrophysiology
Neurology
Infrared radiation
Physiology
Prosthetics
Rats

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Cayce, J. M., Friedman, R., Roe, A., Konrad, P. E., Jansen, E. D., & Mahadevan-Jansen, A. (2010). Relating optical signals induced by infrared neural stimulation to electrophysiology. In Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN [5510836] https://doi.org/10.1109/BSEC.2010.5510836

Relating optical signals induced by infrared neural stimulation to electrophysiology. / Cayce, Jonathan M.; Friedman, Robert; Roe, Anna; Konrad, Peter E.; Jansen, E. Duco; Mahadevan-Jansen, Anita.

Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN. 2010. 5510836.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cayce, JM, Friedman, R, Roe, A, Konrad, PE, Jansen, ED & Mahadevan-Jansen, A 2010, Relating optical signals induced by infrared neural stimulation to electrophysiology. in Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN., 5510836, 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN, Oak Ridge, TN, United States, 5/25/10. https://doi.org/10.1109/BSEC.2010.5510836
Cayce JM, Friedman R, Roe A, Konrad PE, Jansen ED, Mahadevan-Jansen A. Relating optical signals induced by infrared neural stimulation to electrophysiology. In Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN. 2010. 5510836 https://doi.org/10.1109/BSEC.2010.5510836
Cayce, Jonathan M. ; Friedman, Robert ; Roe, Anna ; Konrad, Peter E. ; Jansen, E. Duco ; Mahadevan-Jansen, Anita. / Relating optical signals induced by infrared neural stimulation to electrophysiology. Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN. 2010.
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