Related functions of mGlu4 and mGlu8

Matthew J. Davis, Robert M. Duvoisin, Jacob Raber

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Metabotropic glutamate receptors modulate glutamatergic and GABAergic neurotransmission. Our previous pharmacological data indicate that metabotropic receptor 4 (mGlu4) and metabotropic receptor 8 (mGlu8) might have related and overlapping functions. We explored this by analyzing the behavioral phenotypes of mice deficient in either (mGlu4-/- or mGlu8-/-) or both receptors (mGlu4/8-/-). Our analysis focused on measures of anxiety in the open field and elevated zero maze, sensorimotor function on the rotarod and fear conditioning, as mGlu4 and/or mGlu8 were shown to affect performance in these tests. mGlu8-/- mice weighed more than mGlu4/8-/- mice. In the open field, mGlu4-/- mice showed lower levels of anxiety than mGlu8-/- and mGlu4/8-/- mice. In the elevated zero maze, mGlu4-/- mice showed lower levels of anxiety than wild-type, mGlu8-/- and mGlu4/8-/- mice. In the open field, but not elevated zero maze, mGlu4-/- mice showed lower activity levels than wild-type, mGlu8-/- and mGlu4/8-/- mice. mGlu4/8 -/- female mice showed less contextual freezing than wild-type and mGlu4-/- female mice and there was a trend toward less freezing in male mGlu4/8-/- than wild-type male mice. There were no genotype differences in cued fear conditioning. There were significant negative correlations between body weight and fall latency on the rotarod in wild-type, mGlu8-/- and mGlu4/8-/-, but not mGlu4-/-, mice. These data suggest related functions of mGlu4 and mGlu8 in behavioral performance.

Original languageEnglish (US)
Pages (from-to)11-16
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume111
DOIs
StatePublished - 2013

Keywords

  • Body weight
  • Fear conditioning
  • Open field
  • Zero maze
  • mGlu4
  • mGlu8

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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