Regulatory mechanisms of AMPA receptors in synaptic plasticity

Victor A. Derkach; Michael C. Oh; Eric S. Guire; Thomas R. Soderling

doi:10.1038/nrn2055

Regulatory mechanisms of AMPA receptors in synaptic plasticity

Victor A. Derkach, Michael C. Oh, Eric S. Guire, Thomas R. Soderling

Vollum Institute

Research output: Contribution to journal › Review article › peer-review

564 Scopus citations

Abstract

Activity-dependent changes in the strength of excitatory synapses are a cellular mechanism for the plasticity of neuronal networks that is widely recognized to underlie cognitive functions such as learning and memory. AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-type glutamate receptors (AMPARs) are the main transducers of rapid excitatory transmission in the mammalian CNS, and recent discoveries indicate that the mechanisms which regulate AMPARs are more complex than previously thought. This review focuses on recent evidence that alterations to AMPAR functional properties are coupled to their trafficking, cytoskeletal dynamics and local protein synthesis. These relationships offer new insights into the regulation of AMPARs and synaptic strength by cellular signalling.

Original language	English (US)
Pages (from-to)	101-113
Number of pages	13
Journal	Nature Reviews Neuroscience
Volume	8
Issue number	2
DOIs	https://doi.org/10.1038/nrn2055
State	Published - Feb 2007

ASJC Scopus subject areas

General Neuroscience

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title = "Regulatory mechanisms of AMPA receptors in synaptic plasticity",

abstract = "Activity-dependent changes in the strength of excitatory synapses are a cellular mechanism for the plasticity of neuronal networks that is widely recognized to underlie cognitive functions such as learning and memory. AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-type glutamate receptors (AMPARs) are the main transducers of rapid excitatory transmission in the mammalian CNS, and recent discoveries indicate that the mechanisms which regulate AMPARs are more complex than previously thought. This review focuses on recent evidence that alterations to AMPAR functional properties are coupled to their trafficking, cytoskeletal dynamics and local protein synthesis. These relationships offer new insights into the regulation of AMPARs and synaptic strength by cellular signalling.",

author = "Derkach, {Victor A.} and Oh, {Michael C.} and Guire, {Eric S.} and Soderling, {Thomas R.}",

note = "Funding Information: We thank L. Vaskalis for the exceptional original art work. The authors{\textquoteright} work on AMPARs is supported by a US National Institutes of Health grant to T.R.S. and V.A.D.",

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AU - Guire, Eric S.

AU - Soderling, Thomas R.

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AB - Activity-dependent changes in the strength of excitatory synapses are a cellular mechanism for the plasticity of neuronal networks that is widely recognized to underlie cognitive functions such as learning and memory. AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-type glutamate receptors (AMPARs) are the main transducers of rapid excitatory transmission in the mammalian CNS, and recent discoveries indicate that the mechanisms which regulate AMPARs are more complex than previously thought. This review focuses on recent evidence that alterations to AMPAR functional properties are coupled to their trafficking, cytoskeletal dynamics and local protein synthesis. These relationships offer new insights into the regulation of AMPARs and synaptic strength by cellular signalling.

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Regulatory mechanisms of AMPA receptors in synaptic plasticity

Abstract

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