Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes

Carol Beadling, Kirk M. Druey, Gunther Richter, John H. Kehrl, Kendall A. Smith

    Research output: Contribution to journalArticle

    86 Scopus citations

    Abstract

    The newly recognized regulators of G protein signaling (RGS) attenuate heterotrimeric G protein signaling pathways. We have cloned an IL-2-induced gene from human T cells, cytokine-responsive gene 1, which encodes a member of the RGS family, RGS16. The RGS16 protein binds G(iα) and G(qα) proteins present in T cells, and inhibits G(i)- and G(q)-mediated signaling pathways. By comparison, the mitogen-induced RGS2 inhibits G(q) but not G(i) signaling. Moreover, the two RGS genes exhibit marked differences in expression patterns. The IL-2-induced expression of the RGS16 gene in T cells is suppressed by elevated cAMP, whereas the RGS2 gene shows a reciprocal pattern of regulation by these stimuli. Because the mitogen and cytokine receptors that trigger expression of RGS2 and RGS16 in T cells do not activate heterotrimeric G proteins, these RGS proteins and the G proteins that they regulate may play a heretofore unrecognized role in T cell functional responses to Ag and cytokine activation.

    Original languageEnglish (US)
    Pages (from-to)2677-2682
    Number of pages6
    JournalJournal of Immunology
    Volume162
    Issue number5
    StatePublished - Mar 1 1999

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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