Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes

Carol Beadling, Kirk M. Druey, Gunther Richter, John H. Kehrl, Kendall A. Smith

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

The newly recognized regulators of G protein signaling (RGS) attenuate heterotrimeric G protein signaling pathways. We have cloned an IL-2-induced gene from human T cells, cytokine-responsive gene 1, which encodes a member of the RGS family, RGS16. The RGS16 protein binds G(iα) and G(qα) proteins present in T cells, and inhibits G(i)- and G(q)-mediated signaling pathways. By comparison, the mitogen-induced RGS2 inhibits G(q) but not G(i) signaling. Moreover, the two RGS genes exhibit marked differences in expression patterns. The IL-2-induced expression of the RGS16 gene in T cells is suppressed by elevated cAMP, whereas the RGS2 gene shows a reciprocal pattern of regulation by these stimuli. Because the mitogen and cytokine receptors that trigger expression of RGS2 and RGS16 in T cells do not activate heterotrimeric G proteins, these RGS proteins and the G proteins that they regulate may play a heretofore unrecognized role in T cell functional responses to Ag and cytokine activation.

Original languageEnglish (US)
Pages (from-to)2677-2682
Number of pages6
JournalJournal of Immunology
Volume162
Issue number5
StatePublished - Mar 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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